DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and iqca1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_009300551.1	Gene:	iqca1 / 553364	ZFINID:	ZDB-GENE-050208-768	Length:	845	Species:	Danio rerio

Alignment Length:	521	Identity:	92/521 - (17%)
Similarity:	187/521 - (35%)	Gaps:	134/521 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 QILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTV--- 350
            |:..::..:.|...::...::|:::|              ..|...|::|...|..|..||.
Zfish   334 QVAAEFAAKEEEREKKKKLKSEKDKK--------------ANDRKEKKKGKPKGKGGKGDTEEEE 384

  Fly   351 -------VNQLLTKIDGV----------DQLNNILVIGMTNRRDMIDEALLR-PGRLEVQMEISL 397
                   .|.|.|...|.          |:..|.|        ...|..|:| ..||||::|:
Zfish   385 TGWKMTHSNFLPTVFKGAKLYKEVWQNRDEQQNFL--------QRFDAQLVREEKRLEVEVEL-- 439

  Fly   398 PNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIKAD-- 460
                 |||:..:..:.::....:.|....|:...:.|:....:.:|.....:.....:.:.||
Zfish   440 -----RVQVDELMRQELKNLKLVVDRDKGKKKKKVKKSSKKKKKKGRKTGKKKKKKEKDLTADRT 499

  Fly   461 -----AKVTVDPEAMEKLKVNRDDFLHSLEH--------DIKPAFGTAQEILDNMLARGVINWGA 512
                 .::.::...:..:.|...|::....:        ||:| ..:..::...:...|::..|:
Zfish   500 IESLYEELVLEGIIIRPMNVKLSDYIGEYSYLGTTLRQADIEP-MPSLSDVRQLIALYGILPLGS 563

  Fly   513 PVSNLLEDGMLYVQQAKAPESSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMVG-Y 576
            ...:  |.|.|            :.::|:.|....||..|...|...:......: ||..:.| |
Zfish   564 QCVH--ERGPL------------IRALLLTGPQGVGKKMLVHALCTETGANLFNL-SPSTLAGKY 613

  Fly   577 T-ESAKCLHIRKIFDDAYRSMLSCIVVDNVERLLDYGSI-------GPRYSNMTLQALLVLLKKQ 633
            . :|...|.:..:|..|.:...|.|.:.:.|:.. |..:       .|:....||..:|..:|.:
Zfish   614 PGKSGLQLLLHMVFKVARQLQPSVIWIGDAEKTF-YKKVPKLEKEMEPKRLKKTLPKILKSIKAE 677

  Fly   634 PPKGRKLLILCTSSRREVLEEMEMLTAFTSVLHVPNLSKPDH----------------------- 675
            .    ::|::.||.|....:.......:..::.:|   :||:
Zfish   678 D----RVLVVGTSRRPFDADIKPFCKVYKKIILIP---RPDYASRFTLWKELLQAHGALLDPKLD 735

  Fly   676 VLAVLENTDIFSKGEI-QAIGKKMAGKRVFIGIKKLLGLID----MARQTEQSQRAIKFLSKMEE 735
            :.::.:.||.:::|.| |||...:...|:.:..|:.|..::    :|||..        :.|.||
Zfish   736 LSSLAKVTDGYTQGHILQAIQTILIPHRLELQAKRPLTAVEFIPPLARQDP--------VYKEEE 792

  Fly   736 E 736
            |
Zfish   793 E 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	82/478 (17%)
		AAA	256..397	CDD:278434	26/128 (20%)
		AAA	539..668	CDD:278434	27/137 (20%)
iqca1	XP_009300551.1	SpoVK	<576..748	CDD:223540	32/180 (18%)
iqca1	XP_009300551.1	AAA	576..691	CDD:278434	27/120 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900