DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and PEX6

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_000278.3	Gene:	PEX6 / 5190	HGNCID:	8859	Length:	980	Species:	Homo sapiens

Alignment Length:	330	Identity:	99/330 - (30%)
Similarity:	168/330 - (50%)	Gaps:	50/330 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 GNTVVQFEKAENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFP-- 241
            |..:.|.:.|.:.::   |..|       |.:..|.    .:|||.:    :.:....:...|
Human   680 GQALEQLQTAHSQAV---GAPK-------IPSVSWH----DVGGLQE----VKKEILETIQLPLE 726

  Fly   242 -PELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKI----VNGPQILDKYVGESEAN 301
             |||: .||.:. .|:||:|||||||||:|:.:.|     |..:    |.||::::.|||:||.|
Human   727 HPELL-SLGLRR-SGLLLHGPPGTGKTLLAKAVAT-----ECSLTFLSVKGPELINMYVGQSEEN 784

  Fly   302 VRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNN 366
            ||.:||.|    :...|    .||.|||:|::...||....:.||.|.||:|||.::||:....:
Human   785 VREVFARA----RAAAP----CIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQD 841

  Fly   367 ILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQ-GRVQILNIHTKRMREFNKINDDVDNKEIA 430
            :.|||.|||.|::|.|||||||.:..:.:....:: .::::|:..|::.    |:...|....:.
Human   842 VFVIGATNRPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKF----KLEPSVSLVNVL 902

  Fly   431 -ALTKNFSGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFLHSLEHDIKPAFGT 494
             ......:||:|..|...|.::|:.|.:. |.:..::| ....|.:..:|.|.:... ::|:. :
Human   903 DCCPPQLTGADLYSLCSDAMTAALKRRVH-DLEEGLEP-GSSALMLTMEDLLQAAAR-LQPSV-S 963

  Fly   495 AQEIL 499
            .||:|
Human   964 EQELL 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	88/264 (33%)
		AAA	256..397	CDD:278434	62/144 (43%)
		AAA	539..668	CDD:278434
PEX6	NP_000278.3	SpoVK	463..967	CDD:223540	97/327 (30%)
		AAA	466..594	CDD:278434
		AAA	743..871	CDD:278434	60/140 (43%)
		Vps4_C	918..977	CDD:286426	12/55 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810