DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and PEX1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_000457.1	Gene:	PEX1 / 5189	HGNCID:	8850	Length:	1283	Species:	Homo sapiens

Alignment Length:	453	Identity:	140/453 - (30%)
Similarity:	215/453 - (47%)	Gaps:	72/453 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 RILGNTVVQFEKAENSSLNLQGKSKGKV---VRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFAS 237
            |:...::...||...::|:.|...:|.:   :|...::...|.|...|||| .|...|.......
Human   795 RLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGL-HEVRQILMDTIQL 858

  Fly   238 RVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKI----VNGPQILDKYVGES 298
            ....|||...|..:...||||||||||||||:|..|     |||.::    |.||::|.||:|.|
Human   859 PAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVI-----ARESRMNFISVKGPELLSKYIGAS 918

  Fly   299 EANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQ 363
            |..||.:|..|:..:.        .|:.|||.::|..:||.  .|:||.|.|||||||::|||:.
Human   919 EQAVRDIFIRAQAAKP--------CILFFDEFESIAPRRGH--DNTGVTDRVVNQLLTQLDGVEG 973

  Fly   364 LNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKE 428
            |..:.|:..|:|.|:||.||||||||:..:....|::..|::|||:    :.:...:.||||.:.
Human   974 LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNV----LSDSLPLADDVDLQH 1034

  Fly   429 IAALTKNFSGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFL-HSLEHDIKPAF 492
            :|::|.:|:||:|:.|:..||..|::.::.:.........:...|.::...|| ||...|  .:.
Human  1035 VASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSD--DSA 1097

  Fly   493 GTAQEILDNMLARGVINWGAPVSNLLED-----------GMLYVQQAKAPESSGLVSVLVAGAPN 546
            |..:..||..|.      ...:|.:|.|           |..|..:.....||.|.|..:: ||:
Human  1098 GDGECGLDQSLV------SLEMSEILPDESKFNMYRLYFGSSYESELGNGTSSDLSSQCLS-APS 1155

  Fly   547 S---------GKTALAAQLAKMSDFPFVKVCSPEDMVGYTESAKCLHIRKIFDDAYRSMLSCI 600
            |         ||..|.:|.      |.::..|.|.....|:..:         |..|:.:|.|
Human  1156 SMTQDLPGVPGKDQLFSQP------PVLRTASQEGCQELTQEQR---------DQLRADISII 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	125/384 (33%)
		AAA	256..397	CDD:278434	67/144 (47%)
		AAA	539..668	CDD:278434	15/71 (21%)
PEX1	NP_000457.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..367
		SpoVK	595..1063	CDD:223540	106/287 (37%)
		AAA	595..731	CDD:278434
		AAA	877..1006	CDD:278434	67/143 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1283
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810