DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and Pex1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001102690.1	Gene:	Pex1 / 500006	RGDID:	1559939	Length:	1283	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	140/443 - (31%)
Similarity:	208/443 - (46%)	Gaps:	72/443 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 TVVQFEKAENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELV 245
            |...|:||      |:|.....:...::..|. |.|...|||| .|...|...........|||.
  Rat   810 TTADFQKA------LRGFLPASLRNVNLHKPR-DLGWDKIGGL-HEVRQILMDTIQLPAKYPELF 866

  Fly   246 EQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKI----VNGPQILDKYVGESEANVRRLF 306
            ..|..:...||||||||||||||:|..:     |||..:    :.||::|.||:|.||..||.:|
  Rat   867 ANLPIRQRTGILLYGPPGTGKTLLAGVV-----ARESGMNFISIQGPELLSKYIGASEQAVRDVF 926

  Fly   307 AEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIG 371
            ..|:..:.        .|:.|||.::|..:||.  .|:||.|.|||||||::|||:.|..:.|:.
  Rat   927 IRAQAAKP--------CILFFDEFESIAPRRGH--DNTGVTDRVVNQLLTQLDGVEGLQGVYVLA 981

  Fly   372 MTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNF 436
            .|:|.|:||.||||||||:..:....|::..|::||.:.:|.:    .:.||||.:.:|::|::|
  Rat   982 ATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSL----PLADDVDLQHVASVTESF 1042

  Fly   437 SGAELEGLVRAAQSSAM-NRLIKA---DAKVTVDPEAMEKLKVNRDDFL-HSLEHDIKPAFGTAQ 496
            :||:|:.|:..||..|: .||:..   |...:.|.:    |.::...|| ||...|  .:.|..:
  Rat  1043 TGADLKALLYNAQLEALQGRLLPGGLHDGGSSSDSD----LSLSSMVFLNHSSGSD--DSAGDGE 1101

  Fly   497 EILDNMLARGVINWGAPVSNLLED-----------GMLYVQQAKAPESSGLVSVLVAGAPNSGKT 550
            ..||..|.      ...:|.:|.|           |..|..:.....|..|.|..:: ||:|...
  Rat  1102 CGLDQSLV------SLEMSEILPDESKFNMYRLYFGSSYESELGNGASCDLSSHCLS-APSSMTQ 1159

  Fly   551 ALAAQLAK---MSDFPFVKVCSPEDMVGYTESAKCLHIRKIFDDAYRSMLSCI 600
            .|.|...|   .:..|..:..|.|.....|:..:         |..|:.:|.|
  Rat  1160 DLPATPGKDPLFTQHPVFRTPSQEGSQDLTQEQR---------DQLRADISII 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	125/382 (33%)
		AAA	256..397	CDD:278434	65/144 (45%)
		AAA	539..668	CDD:278434	14/65 (22%)
Pex1	NP_001102690.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		AAA	591..741	CDD:214640
		AAA	595..724	CDD:278434
		AAA	877..1009	CDD:214640	65/146 (45%)
		AAA	877..1006	CDD:278434	65/143 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810