DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and Iqca1l

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001019488.2	Gene:	Iqca1l / 499971	RGDID:	1564789	Length:	822	Species:	Rattus norvegicus

Alignment Length:	731	Identity:	131/731 - (17%)
Similarity:	245/731 - (33%)	Gaps:	204/731 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQSLVFNFKDKKLLGL 148
            :|......|........:||:|.:.|:        :...|:|.||..:..|:...|...:..:|.
  Rat   203 KFSQDQGAIVIQKVWKGYLQRKRIEQD--------RRMEMEFIGMLPSSSQTTRQNALAQAFVGE 259

  Fly   149 AVKSLEAIDPKSLGEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIIN--- 210
            ..:....::            :...|...:..|.....:.|...:..:.|.:   :||..|.
  Rat   260 ESRRTRQVE------------KEEEFQEAIAKTHESLTETEGPDMKERMKDQ---IRQWFIECHA 309

  Fly   211 -----PDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMA 270
                 ||:.....|...|          .||.:.  ||.|.|                   .|.|
  Rat   310 LTGRFPDYPDEASGGSYL----------IFADKT--PEQVRQ-------------------ELEA 343

  Fly   271 RQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICK 335
            :       |:|.|.....:..||...:.|...::    .:||:.:..|.....::....|..|
  Rat   344 Q-------AQENKKKEQEKNKDKVKEKKEKKKKK----TKEEKAKKDPEVMFKVLPSKSIPVI-- 395

  Fly   336 QRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNR---RDMIDEALLRPGRLEVQMEISL 397
                   |:| |:...:...::.|              |:   :....|.|....|.:|:|||
  Rat   396 -------NAG-HEEFTSIWKSRYD--------------NKHPSQSFDSETLREEKRKQVEMEI-- 436

  Fly   398 PNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIKADAK 462
                 |||:..:..:.:|......|..:.:.:.:..|  .|.:..|..:..:....:|.:.:..:
  Rat   437 -----RVQVDELMRQELRNLRLAVDREETRPLKSPKK--KGGKKSGKKKKEKDLTPDRSVDSLFE 494

  Fly   463 VTVDPEAMEK-LKVNRDDFL-------HSLEHDIKPAFGTAQEILDNMLARGVINWGAPVSNLLE 519
            ..|....::| |.|..:|::       .:|....|....:..:|..|:...||:..|:
  Rat   495 ELVVIGLIKKSLLVTLNDYIGDCLYLGSTLTLANKIPMPSLFDIRQNIALYGVLRLGS------- 552

  Fly   520 DGMLYVQQAKAPESSGLV-SVLVAGAPNSGKTALAAQL-----AKMSDFPFVKVCSPEDMV---- 574
                :.....||    || |:|:.|....||..|...:     |.:.|.      ||.:::
  Rat   553 ----HDIHTMAP----LVRSILLVGPSGMGKKMLVQAVCTETGANLFDL------SPGNVMGKYP 603

  Fly   575 GYTESAKCLHIRKIFDDAYRSMLSCIVVDNVERLLDYGSIGPRYSNMTLQAL---LVLLKKQPPK 636
            |...|...:||  :|..|.....|.|.:.|.|:.. |..|......|..:.:   |:...:|...
  Rat   604 GKNGSQLLMHI--VFKVARVFQPSVIWIGNTEKTF-YKKIPKEERRMDPKRIKKDLMRATRQLGP 665

  Fly   637 GRKLLILCTSSRREVLEEMEMLTAFTSVLHVPNLSKPDH-------------------------V 676
            |.:::::.|:.|.::.|...:...:..:|.:|   :||:                         :
  Rat   666 GDRVMLIGTTERPQLAEMKGLCRFYERILFIP---RPDYASRYVLWKRMIENQGIGVQQTQSLDI 727

  Fly   677 LAVLENTDIFSKGEI-QAIGKKMAGKRVFIGIKK----------LLGLIDMARQTEQS------- 723
            .|:...:|.::.|.| |:|...:..:|:....||          |..|..:.|:.|:|
  Rat   728 SALARVSDGYTPGHILQSIQSVLTERRLLQLTKKPLVASEFVVHLAKLDPVYREEEESLKEWFYK 792

  Fly   724 ----QRAIKFLSKMEE 735
                ::.|||....:|
  Rat   793 TPLGKKNIKFTKDQQE 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	7/46 (15%)
		SpoVK	242..699	CDD:223540	93/506 (18%)
		AAA	256..397	CDD:278434	25/143 (17%)
		AAA	539..668	CDD:278434	29/140 (21%)
Iqca1l	NP_001019488.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..378		11/69 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..484		3/28 (11%)
		SpoVK	<563..738	CDD:223540	35/186 (19%)
		AAA	565..698	CDD:278434	30/144 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900