Protein Alignment comt and NVL

DIOPT Version :10

• Sequence 1: NP_524877.1
• Gene: comt / 47091
• FlyBaseID: FBgn0000346
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Alignment Length: 814
• Identity: 198/814 - (24%)
• Similarity: 317/814 - (38%)
• Gaps: 251/814 - (30%)

  Fly    50 EKTVEVPSGYVGFSLVQRKWAMVSINQE----LEVRPYRFDAS---------------------S 89
            |:..:|...:.|||.:.:.|....:..:    |..:|:|:..|                     |
Human    91 EEDNDVSLCHPGFSALAQSWLTAVLTSQAQAILPPQPHRYTESYSDDDSSMEDYPDPQSANHMNS 155

  Fly    90 DVIT--------CVSFETDFLQKKTVSQEPYDSDQM--------AKE-----FIMQFAGMALTVG 133
            .:::        .||...:..|::|.|..|..|.:.        ||:     ||.:...:.
Human   156 SLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVK---- 216

  Fly   134 QSLVFNFKDKKLLGLAVKSLEAIDPK----SLGEGKDTAMRN---VRFGRILGNTVVQFEKAENS 191
                   ||...|.|   |.|..:||    .:.:.||:::..   .|.|: |.|...:.:|.:..
Human   217 -------KDSFFLDL---SCEKSNPKKPITEIQDSKDSSLLESDMKRKGK-LKNKGSKRKKEDLQ 270

  Fly   192 SLN------LQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGC 250
            .::      ||.|:|.:.:...|.|..::    .:||.|.....:.:.....|  .||:...||.
Human   271 EVDGEIEAVLQKKAKARGLEFQISNVKFE----DVGGNDMTLKEVCKMLIHMR--HPEVYHHLGV 329

  Fly   251 KHVKGILLYGPPGTGKTLMARQI-----GTMLNA---------REPKI------------VNGPQ 289
            ...:|:||:||||.||||:|..|     ..|:.|         .:|..            |..|:
Human   330 VPPRGVLLHGPPGCGKTLLAHAIAGAECSGMITAHCSFDFSGSNDPPASASQELDLPILKVAAPE 394

  Fly   290 ILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQL 354
            |:....||||..:|.||.:|        .::...||..||||||..:| .|| :..:...:|.||
Human   395 IVSGVSGESEQKLRELFEQA--------VSNAPCIIFIDEIDAITPKR-EVA-SKDMERRIVAQL 449

  Fly   355 LTKIDGVDQLNN------ILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKR 413
            ||   .:|.|||      :||||.|||.|.:|.||.|.||.:.::.:.:|:|..|.:||....::
Human   450 LT---CMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRK 511

  Fly   414 MREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIK-------------------- 458
            :|    :....|...:|.||..|.||:|..|.|.|...|:||::.
Human   512 LR----LPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGV 572

  Fly   459 ADAKVTVDP-----------------------EAMEKLKVNRDDFLHSLEHDIKPA--------- 491
            .:.::..:|                       |.|:.|.:..:||:.:|. .::|:
Human   573 QEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALS-SVQPSAKREGFVTV 636

  Fly   492 -------FGTAQEILDNMLARGVINWGAPVSNLLEDGMLYVQQAKAPESSGLVS---VLVAGAPN 546
                   .|..::|.:. |...::   |||.|        ..|.||   .|||:   ||:||.|.
Human   637 PNVTWADIGALEDIREE-LTMAIL---APVRN--------PDQFKA---LGLVTPAGVLLAGPPG 686

  Fly   547 SGKTALAAQLAKMSDFPFVKVCSPEDM---VGYTESAKCLHIRKIFDDAYRSMLSCIVVDNVERL 608
            .|||.||..:|..|...|:.|..||.:   ||.:|.|    :|::|..|..|....|..|.|:.|
Human   687 CGKTLLAKAVANESGLNFISVKGPELLNMYVGESERA----VRQVFQRAKNSAPCVIFFDEVDAL 747

  Fly   609 LDYGSIGPRYSNMTLQALLVLLKKQPPKGRKLLILCTSSRREVLEEMEMLTAFTSVLHVPNLSKP 673
            .      ||.|:....|.:.::                  .::|.||:.|.|...|..:...::|
Human   748 C------PRRSDRETGASVRVV------------------NQLLTEMDGLEARQQVFIMAATNRP 788

  Fly   674 DHVLAVLENTDIFSKGEIQAIGKKMAGKRVFIGI 707
            |.:     :..|...|.:.        |.:|:|:
Human   789 DII-----DPAILRPGRLD--------KTLFVGL 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_524877.1	CDC48_N	5..83	CDD:215012	7/36 (19%)
		CDC48_2	111..>158	CDD:215011	12/59 (20%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	69/207 (33%)
		CDC48	<220..>606	CDD:273521	136/482 (28%)
		SpoVK	<526..702	CDD:440232	48/181 (27%)
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247
		CDC48	<277..917	CDD:273521	161/613 (26%)