DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and nmd

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster

Alignment Length:	390	Identity:	109/390 - (27%)
Similarity:	170/390 - (43%)	Gaps:	84/390 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 GMALTVGQSLVFNFKDKKLLGLAVKSL----------EAIDPKSLGEGKDTAMRNVRFGRILGNT 181
            |..|:.||  :|    :.|:.|:|.||          ..:||.|..:.|...:...:..|:
  Fly     8 GSDLSKGQ--IF----QVLVRLSVASLITYYSVKWMMNQMDPTSKNKKKAKVLAEEQLKRL---- 62

  Fly   182 VVQFEKAENSSLNLQGKS----KGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPP 242
                  ||.....|:|:.    :..:....::..|.......|.|||    |:.:....|.|.|.
  Fly    63 ------AEQEGFKLRGQEFSDYELMIASHLVVPADITVSWADIAGLD----SVIQELRESVVLPI 117

  Fly   243 ELVEQLGCKH------VKGILLYGPPGTGKTLMARQIGTMLNAREP--KIVN-GPQIL-DKYVGE 297
            :..:..  ||      .||:||:||||.||||:|:     ..|:|.  :.:| ...|| ||:.||
  Fly   118 QHKDLF--KHSKLWQAPKGVLLHGPPGCGKTLIAK-----ATAKEAGMRFINLDVAILTDKWYGE 175

  Fly   298 SEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVV---NQLLTKID 359
            |:.....:|:.|    .|:.|    .||..||||:..:.|     |...|:...   .|.:...|
  Fly   176 SQKLTSAVFSLA----SRIEP----CIIFIDEIDSFLRSR-----NMNDHEATAMMKTQFMMLWD 227

  Fly   360 GVDQLNN--ILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKIND 422
            |:....|  ::|:|.|||...:|:|::|  |:..|..|.||:|..|..||    |.:.:..:::.
  Fly   228 GLSTNANSTVIVMGATNRPQDLDKAIVR--RMPAQFHIGLPSETQRKDIL----KLILQSEEVSQ 286

  Fly   423 DVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIKADAKVTVDPEA----MEKLKVNRDDFLHS 483
            |||...::.||..|||::|..:.|.|....|.:||     .:.||.|    ...:::..||.|.|
  Fly   287 DVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLI-----TSRDPSATALDRNNVRITMDDLLGS 346

Fly 484 483
Fly 347 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	10/40 (25%)
		SpoVK	242..699	CDD:223540	81/261 (31%)
		AAA	256..397	CDD:278434	49/149 (33%)
		AAA	539..668	CDD:278434
nmd	NP_001285801.1	AAA	132..266	CDD:214640	51/153 (33%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	49/149 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810