DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and spas

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	119/440 - (27%)
Similarity:	183/440 - (41%)	Gaps:	111/440 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 KKTVSQEPYDSDQMAKEFIMQFAGMALTVGQSLVFNFKDKKLLGLAVKSLEAIDPKSLGE----- 163
            |.|.|.:|..|            |..||:|        .|:.:.|||.:.....|::||.
  Fly   362 KATTSAQPTAS------------GRKLTIG--------SKRPVNLAVANKSQTLPRNLGSKTSVG 406

  Fly   164 ------GKDTA-----MRNVRFGRILGNTVVQFEKAENSSLNLQGKSKG---------KVVRQSI 208
                  .|..|     .|....||   ||..|   ...:.:|..|.|..         |.|.|.:
  Fly   407 AVQRQPAKTAATPPAVRRQFSSGR---NTPPQ---RSRTPINNNGPSGSGASTPVVSVKGVEQKL 465

  Fly   209 INPDWDFGKMGIGGLDKEFNSIFRRAFASR------VFP---PELVEQLGCKHVKGILLYGPPGT 264
            :....|  ::..||...|:..|..:..|.:      :.|   |||...|... .||:||:||||.
  Fly   466 VQLILD--EIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAP-AKGLLLFGPPGN 527

  Fly   265 GKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDE 329
            ||||:||.:.|..:|....| :...:..||||:.|..||.|||.|    :.:.|:    ||..||
  Fly   528 GKTLLARAVATECSATFLNI-SAASLTSKYVGDGEKLVRALFAVA----RHMQPS----IIFIDE 583

  Fly   330 IDAICKQRGSVAGNSGVHDT---VVNQLLTKIDGV---DQLNNILVIGMTNRRDMIDEALLRPGR 388
            :|::..:|     :|..|:.   :..:.|.:.||:   ...:.|:|:..|||...:|||.||  |
  Fly   584 VDSLLSER-----SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--R 641

  Fly   389 LEVQMEISLPNEQGRVQILN---------IHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGL 444
            ...::.:|||:||.|..:||         :.|:.:|...||.|.....::.||.|:   |.||.:
  Fly   642 FTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKD---AALEPI 703

  Fly   445 -------VRAAQSSAMNRLIKAD-------AKVTVDPEAMEKLKVNRDDF 480
                   |:....|||..:.:.|       .:.:|.|:::...:....|:
  Fly   704 RELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDY 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	10/46 (22%)
		SpoVK	242..699	CDD:223540	82/268 (31%)
		AAA	256..397	CDD:278434	49/146 (34%)
		AAA	539..668	CDD:278434
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	21/56 (38%)
		AAA	515..652	CDD:214640	53/153 (35%)
		AAA	519..650	CDD:278434	49/146 (34%)
		Vps4_C	<722..754	CDD:286426	4/32 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810