DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and Spata5

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_008759154.1	Gene:	Spata5 / 361935	RGDID:	1310478	Length:	893	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	188/705 - (26%)
Similarity:	309/705 - (43%)	Gaps:	150/705 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VSQEPYDSDQMAKEFIMQFAGMALTVGQSLVFN---FKDKKLLGLAVKSLEAIDPKSLGEGKDTA 168
            |:|.|.|...:..|   :..|:..:...|...|   ..::|||            ||...|..
  Rat   270 VTQSPRDGSGLGLE---EITGLKCSFDSSKEGNTQPISEEKLL------------KSTSAGAK-- 317

  Fly   169 MRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRR 233
                      .||...:..:..:.:||:........:.|.....:|.    ||||:.:..:| |.
  Rat   318 ----------NNTDTFYFISSTTRINLRKICTNSKEQDSQFKVTYDM----IGGLNSQLKAI-RE 367

  Fly   234 AFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGES 298
            .....:..|||.:..|....:|:|||||||||||::||.:...:.| ...::|||:|:.|:.||:
  Rat   368 IIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGA-YVSVINGPEIISKFYGET 431

  Fly   299 EANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQ 363
            ||.:|::||||....    |:    ||..||:||:|.:|  ....|.|...||..|||.:||:..
  Rat   432 EARLRQIFAEATLRH----PS----IIFIDELDALCPKR--EGAQSEVEKRVVASLLTLMDGIGS 486

  Fly   364 LNN---ILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVD 425
            ..:   :||:|.|||...:|.||.||||.:.::||.:||.|.|:.||....:|:...      :.
  Rat   487 EGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHL------LT 545

  Fly   426 NKEIAALTKN---FSGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFLHSLEHD 487
            ..|:..|..|   :.||:|:.|...|...|:.|:::....:. |.:....:|:..:|||..: :|
  Rat   546 KAELLRLANNAHGYVGADLKALCNEAGLYALRRVLRKQPNLP-DSKVAGMVKITLNDFLQGM-ND 608

  Fly   488 IKPAFGTAQEI---LDNMLARGVINWGAPVSNL--LEDGMLYVQQA-----KAPESSGLV----- 537
            |:|:  ..:|:   :.|      ::|    |::  ||:..|.::||     |.|:|...:
  Rat   609 IRPS--AMREVAIDVPN------VSW----SDIGGLENIKLKLKQAVEWPLKHPKSFSRMGIQPP 661

  Fly   538 -SVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDM---VGYTESAKCLHIRKIFDDAYRSMLS 598
             .||:.|.|...||.:|..||..|...|:.:..||.|   ||.:|.|    :|::|..|.....|
  Rat   662 KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERA----VREVFRKARAVAPS 722

  Fly   599 CIVVDNVERL-LDYGSIGPRYSNMTLQALLVLLKKQP--PKGRKLLILCTSSRREVLEEMEMLTA 660
            .|..|.::.| ::.|| .....|:..:.|..||.:..  .:.:.:.:|..::|.:.:::..|...
  Rat   723 IIFFDELDALAVERGS-SSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPG 786

  Fly   661 -FTSVLHVPNLSKPD------------HVLAV---------LENTDIFSKGEIQAIGKKMAGKRV 703
             ...:::||   .||            |.:.:         :..||.:|..||.|:.|:.|
  Rat   787 RIDRIIYVP---LPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAEIIAVCKEAA---- 844

  Fly   704 FIGIKKLLGLID-------MARQTEQSQRAI---------KFLSKMEEEGGLDMV 742
                  ||.|.:       |.|...|:...:         :|....:|:.||.||
  Rat   845 ------LLALEENIKADCIMKRHFTQALSIVTPRIPESLRRFYEDYQEKSGLHMV 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	9/49 (18%)
		SpoVK	242..699	CDD:223540	149/506 (29%)
		AAA	256..397	CDD:278434	61/143 (43%)
		AAA	539..668	CDD:278434	34/135 (25%)
Spata5	XP_008759154.1	CDC48_N	64..132	CDD:304500
		SpoVK	370..882	CDD:223540	157/560 (28%)
		AAA	390..522	CDD:278434	60/142 (42%)
		AAA	664..796	CDD:278434	36/139 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810