DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and vcp

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_958889.1	Gene:	vcp / 327197	ZFINID:	ZDB-GENE-030131-5408	Length:	806	Species:	Danio rerio

Alignment Length:	618	Identity:	179/618 - (28%)
Similarity:	285/618 - (46%)	Gaps:	120/618 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 AMRNVRFGRIL----GNTVVQFEKAE-----------NSSLNLQGKSKGKVVRQSIINPDWDFGK 217
            |.|.:|.|.|.    |...|:|:..|           ::.::.:|:...:...:..:|   :.|.
Zfish   142 AYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLN---EVGY 203

  Fly   218 MGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREP 282
            ..|||:.|:...| :......:..|.|.:.:|.|..:||||||||||||||:||.:     |.|.
Zfish   204 DDIGGVRKQLAQI-KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV-----ANET 262

  Fly   283 K----IVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGN 343
            .    ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||..:|....|.
Zfish   263 GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREKTHGE 319

  Fly   344 SGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILN 408
              |...:|:||||.:||:.|..:::|:..|||.:.||.||.|.||.:.:::|.:|:..||::||.
Zfish   320 --VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQ 382

  Fly   409 IHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNR---LIKADAKVTVDPEAM 470
            ||||.|    |:.||||.:::|..|....||:|..|...|...|:.:   ||..:.: |:|.|.|
Zfish   383 IHTKNM----KLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDE-TIDAEVM 442

  Fly   471 EKLKVNRDDFLHSLEHDIKPAF-GTAQEI----------LDNML--ARGVINWGAPVSN---LLE 519
            ..|.|..|||..:|......|. .|..|:          ||::.  .:.::.:  ||.:   .|:
Zfish   443 NSLAVTMDDFRWALSQSNPSALRETVVEVPNITWEDIGGLDDVKRELQELVQY--PVEHPDKFLK 505

  Fly   520 DGMLYVQQAKAPESSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMV---GYTESAK 581
            .||        ..|.|   ||..|.|..|||.||..:|......|:.:..||.:.   |.:|:
Zfish   506 FGM--------TPSKG---VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEA-- 557

  Fly   582 CLHIRKIFDDAYRSMLSCIV----VDNVER-----LLDYGSIGPRYSNMTLQALLVLLKKQPPKG 637
              ::|:|||.| |....|::    :|::.:     :.|.|....|..|..|..:..:..|
Zfish   558 --NVREIFDKA-RQAAPCVLFFDELDSIAKARGGNVGDGGGAADRVINQILTEMDGMSSK----- 614

  Fly   638 RKLLILCTSSRREVLEEMEMLTA-FTSVLHVPNLSKPDH------VLAVLENTDIFSKGEIQAIG 695
            :.:.|:..::|.::::...:... ...::::|   .||.      :.|.|..:.|....::..:.
Zfish   615 KNVFIIGATNRPDIIDPAILRPGRLDQLIYIP---LPDEKSRIAILKANLRKSPISKDVDLDFLA 676

  Fly   696 KKMAGKRVFIGIKKLLGLIDMARQTEQSQRAIK 728
            |...|   |.|          |..||..|||.|
Zfish   677 KMTNG---FSG----------ADLTEICQRACK 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	152/498 (31%)
		AAA	256..397	CDD:278434	62/144 (43%)
		AAA	539..668	CDD:278434	31/141 (22%)
vcp	NP_958889.1	CDC48	25..764	CDD:273521	179/618 (29%)
		CDC48_N	25..107	CDD:280513
		CDC48_2	131..191	CDD:215011	10/48 (21%)
		AAA	241..370	CDD:278434	61/143 (43%)
		P-loop_NTPase	452..>534	CDD:304359	24/94 (26%)
		AAA	514..647	CDD:278434	32/145 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Vps4_C	<718..760	CDD:286426
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810