DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and Trip13

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001011930.1	Gene:	Trip13 / 292206	RGDID:	1308516	Length:	432	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	95/461 - (20%)
Similarity:	178/461 - (38%)	Gaps:	104/461 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DASSDV---ITCV----SFETDFLQ-------KKTVSQEPYDSDQMAKEFIMQFAGMALTVGQSL 136
            ||..|:   :.||    :...:.||       |:.:.|..|   ::.|...:.|.        ..
  Rat     3 DAVGDLKQALPCVAESPAVHVEVLQRSGSTAKKEDIKQSVY---RLLKRHNIVFG--------DY 56

  Fly   137 VFNFKDKKLLGLAVKS-------LEAIDPKSLGEGKDTAMRNVRFGRILGNTVVQFEKAENSSLN 194
            |:...|:..|...|:|       |:|.||:.:.....|          :...:.|..:...||.|
  Rat    57 VWTEFDEPFLTRNVQSVSIVDTELKAKDPQPIDLSACT----------IALHIFQLNEEGPSSEN 111

  Fly   195 LQGKSKGKVVRQSIINPDWDFGKMGIGGL------DKEFNS-IFRRAFASRVFPPELVEQLGCKH 252
            |..:::..:.....:.|..:|     .||      |.|..| :......:.:|..:.|:......
  Rat   112 LDEETENIIAASHWVLPAAEF-----HGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVDSNLITW 171

  Fly   253 VKGILLYGPPGTGKTLMARQIGTMLNAR--------EPKIVNGPQILDKYVGESEANVRRLFAEA 309
            .:.:||:||||||||.:.:.:...|..|        :...:|...:..|:..||...|.::|.:.
  Rat   172 NRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKI 236

  Fly   310 EEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDT--VVNQLLTKIDGVDQLNNILVIGM 372
            ::   .:.....|..::.||::::...|.:....:...|.  |||.:||:||.:.:.:|::::..
  Rat   237 QD---LIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRVVNAVLTQIDQIKRHSNVVILTT 298

  Fly   373 TNRRDMIDEALLRPGRLEVQMEISLPNEQG--------------------RVQILNIHTKRMREF 417
            :|..:.||.|.:  .|.:::..|..|:...                    |.|:|.:....|..|
  Rat   299 SNITEKIDVAFV--DRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGF 361

  Fly   418 NKINDDVDN-----KEIAALTKNFSGAEL-------EGLVRAAQSSAMNRLIKADAKVTVDPEAM 470
              |.::|..     .||:..::..||..|       ..|...|.|..:...::| ..:.||.:..
  Rat   362 --IENNVSKLSLLLSEISRKSEGLSGRVLRKLPFLAHALYIQAPSVTIEGFLQA-LSLAVDKQFE 423

  Fly   471 EKLKVN 476
            ||.|::
  Rat   424 EKKKLS 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	10/53 (19%)
		SpoVK	242..699	CDD:223540	60/277 (22%)
		AAA	256..397	CDD:278434	37/150 (25%)
		AAA	539..668	CDD:278434
Trip13	NP_001011930.1	RecA-like_Pch2-like	121..319	CDD:410916	45/207 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810