DRSC/TRiP Functional Genomics Resources

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Protein Alignment comt and Vcp

DIOPT Version :9

Sequence 1:NP_001259506.1 Gene:comt / 47091 FlyBaseID:FBgn0000346 Length:745 Species:Drosophila melanogaster
Sequence 2:NP_033529.3 Gene:Vcp / 269523 MGIID:99919 Length:806 Species:Mus musculus


Alignment Length:619 Identity:176/619 - (28%)
Similarity:283/619 - (45%) Gaps:122/619 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 AMRNVRFGRIL----GNTVVQFEKAE-----------NSSLNLQGKSKGKVVRQSIINPDWDFGK 217
            |.|.:|.|.|.    |...|:|:..|           ::.::.:|:...:...:..:|   :.|.
Mouse   142 AYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLN---EVGY 203

  Fly   218 MGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREP 282
            ..|||..|:...| :......:..|.|.:.:|.|..:||||||||||||||:||.:     |.|.
Mouse   204 DDIGGCRKQLAQI-KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV-----ANET 262

  Fly   283 K----IVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGN 343
            .    ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||..:|....|.
Mouse   263 GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREKTHGE 319

  Fly   344 SGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILN 408
              |...:|:||||.:||:.|..:::|:..|||.:.||.||.|.||.:.:::|.:|:..||::||.
Mouse   320 --VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQ 382

  Fly   409 IHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNR---LIKADAKVTVDPEAM 470
            ||||.|    |:.||||.:::|..|....||:|..|...|...|:.:   ||..:.: |:|.|.|
Mouse   383 IHTKNM----KLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDE-TIDAEVM 442

  Fly   471 EKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINW---GAPVSNLLEDGMLYVQQ----- 527
            ..|.|..|||..:|......|      :.:.::....:.|   |.     |||....:|:     
Mouse   443 NSLAVTMDDFRWALSQSNPSA------LRETVVEVPQVTWEDIGG-----LEDVKRELQELVQYP 496

  Fly   528 AKAPE---------SSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMV---GYTESA 580
            .:.|:         |.|   ||..|.|..|||.||..:|......|:.:..||.:.   |.:|: 
Mouse   497 VEHPDKFLKFGMTPSKG---VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEA- 557

  Fly   581 KCLHIRKIFDDAYRSMLSCIV----VDNVER-----LLDYGSIGPRYSNMTLQALLVLLKKQPPK 636
               ::|:|||.| |....|::    :|::.:     :.|.|....|..|..|..:..:..|    
Mouse   558 ---NVREIFDKA-RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTK---- 614

  Fly   637 GRKLLILCTSSRREVLEEMEMLTA-FTSVLHVPNLSKPDH------VLAVLENTDIFSKGEIQAI 694
             :.:.|:..::|.::::...:... ...::::|   .||.      :.|.|..:.:....:::.:
Mouse   615 -KNVFIIGATNRPDIIDPAILRPGRLDQLIYIP---LPDEKSRVAILKANLRKSPVAKDVDLEFL 675

  Fly   695 GKKMAGKRVFIGIKKLLGLIDMARQTEQSQRAIK 728
            .|...|   |.|          |..||..|||.|
Mouse   676 AKMTNG---FSG----------ADLTEICQRACK 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
comtNP_001259506.1 CDC48_N 5..83 CDD:215012
CDC48_2 111..>158 CDD:215011
SpoVK 242..699 CDD:223540 149/499 (30%)
AAA 256..397 CDD:278434 62/144 (43%)
AAA 539..668 CDD:278434 31/141 (22%)
VcpNP_033529.3 CDC48 25..764 CDD:273521 176/619 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..727
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..806
Interaction with UBXN6. /evidence=ECO:0000250 797..806
PIM motif. /evidence=ECO:0000250|UniProtKB:P55072 802..806
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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