DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and Nsf

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_032766.2	Gene:	Nsf / 18195	MGIID:	104560	Length:	744	Species:	Mus musculus

Alignment Length:	734	Identity:	464/734 - (63%)
Similarity:	576/734 - (78%)	Gaps:	3/734 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKATKCPTDELSLTNRAIVNVGDFPEEIKYADISPAPGQHFIFALEKTVEVPSGYVGFSLVQRKW 69
            ::|.:||||||||:|.|:||..|| :..::..:..:|...:||.|.....|..|.:.|||.||||
Mouse     6 MQAARCPTDELSLSNCAVVNEKDF-QSGQHVMVRTSPNHKYIFTLRTHPSVVPGCIAFSLPQRKW 69

  Fly    70 AMVSINQELEVRPYRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQ 134
            |.:||.|::||..|.||.:...|..::.|.||||||.:...|||:|:||.|||.||...|.:|||
Mouse    70 AGLSIGQDIEVALYSFDKAKQCIGTMTIEIDFLQKKNIDSNPYDTDKMAAEFIQQFNNQAFSVGQ 134

  Fly   135 SLVFNFKDKKLLGLAVKSLEAIDPKSL-GEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGK 198
            .|||:|.| ||.||.||.:||:||..| ||......:.:..|.::||:.|.|||||||||||.||
Mouse   135 QLVFSFND-KLFGLLVKDIEAMDPSILKGEPASGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGK 198

  Fly   199 SKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPG 263
            :|.|..|||||||||:|.|||||||||||:.||||||||||||||:|||:|||||||||||||||
Mouse   199 AKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPG 263

  Fly   264 TGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFD 328
            .||||:|||||.||||||||:||||:||:|||||||||:|:|||:||||::|||.||||||||||
Mouse   264 CGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFD 328

  Fly   329 EIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQM 393
            |||||||||||:||::|||||||||||:|||||:|||||||||||||.|:|||||||||||||:|
Mouse   329 EIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKM 393

  Fly   394 EISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIK 458
            ||.||:|:||:|||:|||.|||....::.|||.||:|..||||||||||||||||||:||||.||
Mouse   394 EIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIK 458

  Fly   459 ADAKVTVDPEAMEKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINWGAPVSNLLEDGML 523
            |..||.||.|..|.|:|.|.|||.|||:||||||||.||...:.:..|:|.||.||:.:|:||.|
Mouse   459 ASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGEL 523

  Fly   524 YVQQAKAPESSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMVGYTESAKCLHIRKI 588
            .|||.|..:.:.|||||:.|.|:||||||||::|:.|:|||:|:|||:.|:|::|:|||..::||
Mouse   524 LVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKI 588

  Fly   589 FDDAYRSMLSCIVVDNVERLLDYGSIGPRYSNMTLQALLVLLKKQPPKGRKLLILCTSSRREVLE 653
            |||||:|.|||:|||::||||||..||||:||:.||||||||||.||:||||||:.|:||::||:
Mouse   589 FDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQ 653

  Fly   654 EMEMLTAFTSVLHVPNLSKPDHVLAVLENTDIFSKGEIQAIGKKMAGKRVFIGIKKLLGLIDMAR 718
            |||||.||::.:||||::..:.:|..||....|...|...|.:::.||:|:|||||||.||:|:.
Mouse   654 EMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSL 718

  Fly   719 QTEQSQRAIKFLSKMEEEG 737
            |.:...|..|||:.|.|||
Mouse   719 QMDPEYRVRKFLALMREEG 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012	34/77 (44%)
		CDC48_2	111..>158	CDD:215011	28/46 (61%)
		SpoVK	242..699	CDD:223540	312/456 (68%)
		AAA	256..397	CDD:278434	120/140 (86%)
		AAA	539..668	CDD:278434	84/128 (66%)
Nsf	NP_032766.2	CDC48_N	6..83	CDD:215012	34/77 (44%)
		CDC48_2	111..183	CDD:215011	36/72 (50%)
		AAA	254..399	CDD:214640	123/144 (85%)
		AAA	256..397	CDD:278434	120/140 (86%)
		AAA	538..670	CDD:214640	87/131 (66%)
		AAA	539..668	CDD:278434	84/128 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837853
Domainoid	1	1.000	247	1.000	Domainoid score	I2152
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4502
Inparanoid	1	1.050	906	1.000	Inparanoid score	I371
Isobase	1	0.950	-	0	Normalized mean entropy	S525
OMA	1	1.010	-	-		QHG52406
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003053
OrthoInspector	1	1.000	-	-		otm42921
orthoMCL	1	0.900	-	-		OOG6_101440
Panther	1	1.100	-	-	LDO	PTHR23078
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1308
SonicParanoid	1	1.000	-	-		X2410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740