DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment comt and figl-1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_504197.1	Gene:	figl-1 / 178829	WormBaseID:	WBGene00017981	Length:	594	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	98/380 - (25%)
Similarity:	160/380 - (42%)	Gaps:	98/380 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 KKLLGLAVKSLEAIDPKSLGEGKDTAMRNVRFGRIL---GNTVVQFEKAENSSLN---------- 194
            :|.:|:..:          |.|||..|..:|....|   ...::...::|..|:|
Worm   266 RKAMGMDTE----------GGGKDEKMSGLRAEPTLKHFDENIISLIESEIMSVNNEIGWADVAG 320

  Fly   195 LQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRR--AFASRVFPPELVEQLGCKHVKGIL 257
            |:|..  |.:|:.::.|                   |:|  .|.....||           ||:|
Worm   321 LEGAK--KALREIVVLP-------------------FKRPDVFTGIRAPP-----------KGVL 353

  Fly   258 LYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGL 322
            |:||||||||::.|.:.:...|....| :...:..|:|||.|..||.||:.|     ||...|
Worm   354 LFGPPGTGKTMIGRCVASQCKATFFNI-SASSLTSKWVGEGEKLVRALFSVA-----RLKLPS-- 410

  Fly   323 HIIIFDEIDAICKQRGSVAGNSGVHDT---VVNQLLTKIDGVDQL--NNILVIGMTNRRDMIDEA 382
             :|..||||::...|     :...|::   :..:.|.::|||:..  ..:||:|.|||...:|||
Worm   411 -VIFIDEIDSLLSSR-----SESEHESSRRIKTEFLVQLDGVNTAPDERLLVLGATNRPQELDEA 469

  Fly   383 LLRPGRLEVQMEISLPNEQGRVQI---LNIHTKRMREFNKINDDVDN---KEIAALTKNFSGAEL 441
            ..|  |.:.::.|:||..:.|.||   |.:.|:.         |:.|   :.|..||..:|||::
Worm   470 ARR--RFQKRLYIALPEPESRTQIVQNLLVGTRH---------DITNHNLERIRELTDGYSGADM 523

  Fly   442 EGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFLHSLEHDIKPAFGTAQ 496
            ..|...|....:..:  .|...|:|.:.:..:.|.  ||..: ...::|....:|
Worm   524 RQLCTEAAMGPIRDI--GDDIETIDKDDIRAVTVM--DFAEA-ARVVRPTVDDSQ 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011	2/14 (14%)
		SpoVK	242..699	CDD:223540	77/266 (29%)
		AAA	256..397	CDD:278434	49/145 (34%)
		AAA	539..668	CDD:278434
figl-1	NP_504197.1	P-loop_NTPase	315..>371	CDD:304359	23/87 (26%)
		AAA	348..484	CDD:214640	54/162 (33%)
		AAA	352..480	CDD:278434	48/143 (34%)
		Vps4_C	<545..585	CDD:286426	6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900