DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment comt and mac-1

DIOPT Version :9

Sequence 1:	NP_001259506.1	Gene:	comt / 47091	FlyBaseID:	FBgn0000346	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_496814.1	Gene:	mac-1 / 174974	WormBaseID:	WBGene00003119	Length:	813	Species:	Caenorhabditis elegans

Alignment Length:	820	Identity:	193/820 - (23%)
Similarity:	327/820 - (39%)	Gaps:	217/820 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PTDELSLTNRAIVNVGDF-------PEEIKYADISPAPGQ-----HFIF------ALEKTVEVPS 57
            |:|. :|..|...::..|       ||.:.| |:.....:     |.:|      |||: :::.:
Worm     8 PSDP-ALLPRVQAHIRKFPGTKYFKPELVAY-DLQQEHPEYQRKNHKVFMGMVREALER-IQLVA 69

  Fly    58 GYVGFSLVQRKWAM-----VSINQELEVRPYRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQM 117
            .......::.|.||     :.|.:.||.|..:..|:....|..:...    |:.|..:..:.::.
Worm    70 KEENDEKMEEKEAMDDVQEIPIVKALETRKRKAPAAGRKSTGQAAAA----KEVVLSDDSEDERA 130

  Fly   118 AKEFIMQFAGMALTVGQSLVFNFKDKKLLGLAVKSLEAIDPKSLGEGKDTAMRNVRFGRILGNTV 182
            |::...|.        :||..|..:|.:|.|..|......|.|..:.:.|
Worm   131 ARQLEKQI--------ESLKTNRANKTVLNLYTKKSAPSTPVSTPKNQAT--------------- 172

  Fly   183 VQFEKAENSSLNLQGKSKGKVVRQSIINPDWDFGKM-GIGGLDKEFNSIFRRAFASRVFPPELVE 246
               :|...:|.......:|.......|:|.....|. .|||.|::|..:.|  .|..:..|:...
Worm   173 ---KKPPGASAAPPALPRGLGAVSDTISPRESHVKFEHIGGADRQFLEVCR--LAMHLKRPKTFA 232

  Fly   247 QLGCKHVKGILLYGPPGTGKTLMARQIG-----TMLNAREPKIVNGPQILDKYVGESEANVRRLF 306
            .||....:|.:::||||.|||:.|:.:.     .||.....::|:|..      ||:|..:||||
Worm   233 TLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVS------GETEEKIRRLF 291

  Fly   307 AEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGV---------- 361
            ..|::       ||.. |:|.|:||||..:|.:  ....:...||:||.:.:|.:
Worm   292 DTAKQ-------NSPC-ILILDDIDAIAPRRET--AQREMERRVVSQLCSSLDELVLPPREKPLK 346

  Fly   362 DQLN-------------------NILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQIL 407
            |||.                   .:||||.|:|.|.:|..|.|.||.|.::.:.:|:|..|.:||
Worm   347 DQLTFGDDGSVAIIGDSPTAAGAGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKIL 411

  Fly   408 NIHTKRMREFNKIN--DDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLI-------KADAKV 463
                   .:..|:|  .||..|:||.||..:.||:|:.|:|.|...|::|:.       :....:
Worm   412 -------EKICKVNLAGDVTLKQIAKLTPGYVGADLQALIREAAKVAIDRVFDTIVVKNEGHKNL 469

  Fly   464 TV------------------DPEAMEK----LKVNRDDFLHSLEHDIKPA-----FGTAQEILDN 501
            ||                  ||.|:.:    |:::.:||..:|. .|:||     |.|..:
Worm   470 TVEQIKEELDRVLAWLQGDDDPSALSELNGGLQISFEDFERALS-TIQPAAKREGFATVPD---- 529

  Fly   502 MLARGVINW---GA--PVSNLLEDGMLY-VQQAKAPESSGL----VSVLVAGAPNSGKTALAAQL 556
                  ::|   ||  .|...||..:|| :::|....:.|:    ..:|:.|.|..|||.||..:
Worm   530 ------VSWDDIGALVEVRKQLEWSILYPIKRADDFAALGIDCRPQGILLCGPPGCGKTLLAKAV 588

  Fly   557 AKMSDFPFVKVCSPEDM---VGYTESAKCLHIRKIFDDAYRSMLSCIVVDNVERLLDYGSIGPRY 618
            |..:...|:.|..||.:   ||.:|.|    :|.:|..|..|....|..|.::.|:...|.|
Worm   589 ANETGMNFISVKGPELLNMYVGESERA----VRTVFQRARDSQPCVIFFDEIDALVPKRSHG--- 646

  Fly   619 SNMTLQALLVLLKKQPPKGRKLLILCTSSRREVLEEMEMLTAFTSVLHVPNLSKPDHVLAVLENT 683
                          :...|.:|:       .::|.||:.:.....|..:...::||.|.|.
Worm   647 --------------ESSGGARLV-------NQLLTEMDGVEGRQKVFLIGATNRPDIVDAA---- 686

  Fly   684 DIFSKGEIQAIGKKMAGKRVFIGIKKLLGLIDMARQTEQS 723
             |...|.:..|        :|:....:...:|:.|::.::
Worm   687 -ILRPGRLDKI--------LFVDFPSVEDRVDILRKSTKN 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012	21/94 (22%)
		CDC48_2	111..>158	CDD:215011	9/46 (20%)
		SpoVK	242..699	CDD:223540	140/539 (26%)
		AAA	256..397	CDD:278434	51/174 (29%)
		AAA	539..668	CDD:278434	32/131 (24%)
mac-1	NP_496814.1	Nucleolin_bd	5..65	CDD:318849	14/59 (24%)
mac-1	NP_496814.1	TIP49	<191..804	CDD:332389	153/604 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810