DRSC/TRiP Functional Genomics Resources

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Protein Alignment comt and Vcp

DIOPT Version :10

Sequence 1:NP_524877.1 Gene:comt / 47091 FlyBaseID:FBgn0000346 Length:745 Species:Drosophila melanogaster
Sequence 2:NP_446316.1 Gene:Vcp / 116643 RGDID:621595 Length:806 Species:Rattus norvegicus


Alignment Length:619 Identity:176/619 - (28%)
Similarity:283/619 - (45%) Gaps:122/619 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 AMRNVRFGRIL----GNTVVQFEKAE-----------NSSLNLQGKSKGKVVRQSIINPDWDFGK 217
            |.|.:|.|.|.    |...|:|:..|           ::.::.:|:...:...:..:|   :.|.
  Rat   142 AYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLN---EVGY 203

  Fly   218 MGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREP 282
            ..|||..|:...| :......:..|.|.:.:|.|..:||||||||||||||:||.:     |.|.
  Rat   204 DDIGGCRKQLAQI-KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV-----ANET 262

  Fly   283 K----IVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGN 343
            .    ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||..:|....|.
  Rat   263 GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREKTHGE 319

  Fly   344 SGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILN 408
              |...:|:||||.:||:.|..:::|:..|||.:.||.||.|.||.:.:::|.:|:..||::||.
  Rat   320 --VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQ 382

  Fly   409 IHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNR---LIKADAKVTVDPEAM 470
            ||||.|    |:.||||.:::|..|....||:|..|...|...|:.:   ||..:.: |:|.|.|
  Rat   383 IHTKNM----KLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDE-TIDAEVM 442

  Fly   471 EKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINW---GAPVSNLLEDGMLYVQQ----- 527
            ..|.|..|||..:|......|      :.:.::....:.|   |.     |||....:|:     
  Rat   443 NSLAVTMDDFRWALSQSNPSA------LRETVVEVPQVTWEDIGG-----LEDVKRELQELVQYP 496

  Fly   528 AKAPE---------SSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMV---GYTESA 580
            .:.|:         |.|   ||..|.|..|||.||..:|......|:.:..||.:.   |.:|: 
  Rat   497 VEHPDKFLKFGMTPSKG---VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEA- 557

  Fly   581 KCLHIRKIFDDAYRSMLSCIV----VDNVER-----LLDYGSIGPRYSNMTLQALLVLLKKQPPK 636
               ::|:|||.| |....|::    :|::.:     :.|.|....|..|..|..:..:..|    
  Rat   558 ---NVREIFDKA-RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTK---- 614

  Fly   637 GRKLLILCTSSRREVLEEMEMLTA-FTSVLHVPNLSKPDH------VLAVLENTDIFSKGEIQAI 694
             :.:.|:..::|.::::...:... ...::::|   .||.      :.|.|..:.:....:::.:
  Rat   615 -KNVFIIGATNRPDIIDPAILRPGRLDQLIYIP---LPDEKSRVAILKANLRKSPVAKDVDLEFL 675

  Fly   695 GKKMAGKRVFIGIKKLLGLIDMARQTEQSQRAIK 728
            .|...|   |.|          |..||..|||.|
  Rat   676 AKMTNG---FSG----------ADLTEICQRACK 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
comtNP_524877.1 CDC48_N 5..83 CDD:215012
CDC48_2 111..>158 CDD:215011
RecA-like_NSF-SEC18_r1-like 219..395 CDD:410912 71/179 (40%)
CDC48 <220..>606 CDD:273521 140/416 (34%)
SpoVK <526..702 CDD:440232 42/208 (20%)
VcpNP_446316.1 CDC48 25..764 CDD:273521 176/619 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..727
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..806
Interaction with UBXN6. /evidence=ECO:0000250 797..806
PIM motif. /evidence=ECO:0000250|UniProtKB:P55072 802..806
Blue background indicates that the domain is not in the aligned region.

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