Protein Alignment comt and Vcp

DIOPT Version :9

• Sequence 1: NP_001259506.1
• Gene: comt / 47091
• FlyBaseID: FBgn0000346
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_446316.1
• Gene: Vcp / 116643
• RGDID: 621595
• Length: 806
• Species: Rattus norvegicus
• Alignment Length: 619
• Identity: 176/619 - (28%)
• Similarity: 283/619 - (45%)
• Gaps: 122/619 - (19%)

  Fly   168 AMRNVRFGRIL----GNTVVQFEKAE-----------NSSLNLQGKSKGKVVRQSIINPDWDFGK 217
            |.|.:|.|.|.    |...|:|:..|           ::.::.:|:...:...:..:|   :.|.
  Rat   142 AYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLN---EVGY 203

  Fly   218 MGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREP 282
            ..|||..|:...| :......:..|.|.:.:|.|..:||||||||||||||:||.:     |.|.
  Rat   204 DDIGGCRKQLAQI-KEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV-----ANET 262

  Fly   283 K----IVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGN 343
            .    ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||..:|....|.
  Rat   263 GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREKTHGE 319

  Fly   344 SGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILN 408
              |...:|:||||.:||:.|..:::|:..|||.:.||.||.|.||.:.:::|.:|:..||::||.
  Rat   320 --VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQ 382

  Fly   409 IHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNR---LIKADAKVTVDPEAM 470
            ||||.|    |:.||||.:::|..|....||:|..|...|...|:.:   ||..:.: |:|.|.|
  Rat   383 IHTKNM----KLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDE-TIDAEVM 442

  Fly   471 EKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINW---GAPVSNLLEDGMLYVQQ----- 527
            ..|.|..|||..:|......|      :.:.::....:.|   |.     |||....:|:
  Rat   443 NSLAVTMDDFRWALSQSNPSA------LRETVVEVPQVTWEDIGG-----LEDVKRELQELVQYP 496

  Fly   528 AKAPE---------SSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMV---GYTESA 580
            .:.|:         |.|   ||..|.|..|||.||..:|......|:.:..||.:.   |.:|:
  Rat   497 VEHPDKFLKFGMTPSKG---VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEA- 557

  Fly   581 KCLHIRKIFDDAYRSMLSCIV----VDNVER-----LLDYGSIGPRYSNMTLQALLVLLKKQPPK 636
               ::|:|||.| |....|::    :|::.:     :.|.|....|..|..|..:..:..|
  Rat   558 ---NVREIFDKA-RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTK---- 614

  Fly   637 GRKLLILCTSSRREVLEEMEMLTA-FTSVLHVPNLSKPDH------VLAVLENTDIFSKGEIQAI 694
             :.:.|:..::|.::::...:... ...::::|   .||.      :.|.|..:.:....:::.:
  Rat   615 -KNVFIIGATNRPDIIDPAILRPGRLDQLIYIP---LPDEKSRVAILKANLRKSPVAKDVDLEFL 675

  Fly   695 GKKMAGKRVFIGIKKLLGLIDMARQTEQSQRAIK 728
            .|...|   |.|          |..||..|||.|
  Rat   676 AKMTNG---FSG----------ADLTEICQRACK 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012
		CDC48_2	111..>158	CDD:215011
		SpoVK	242..699	CDD:223540	149/499 (30%)
		AAA	256..397	CDD:278434	62/144 (43%)
		AAA	539..668	CDD:278434	31/141 (22%)
Vcp	NP_446316.1	CDC48	25..764	CDD:273521	176/619 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000250	797..806
		PIM motif. /evidence=ECO:0000250|UniProtKB:P55072	802..806

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810