Protein Alignment acj6 and POU5F1

DIOPT Version :10

• Sequence 1: NP_524876.1
• Gene: acj6 / 47080
• FlyBaseID: FBgn0000028
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_002692.2
• Gene: POU5F1 / 5460
• HGNCID: 9221
• Length: 360
• Species: Homo sapiens
• Alignment Length: 165
• Identity: 77/165 - (46%)
• Similarity: 106/165 - (64%)
• Gaps: 16/165 - (9%)

  Fly   220 HPDTDTD----PRELEAFAERFKQRRIKLGVTQADVGKALANLKLPGV---GALSQSTICRFESL 277
            :|:...|    .:|||.||:..||:||.||.||||||..|      ||   ...||:||||||:|
Human   132 NPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTL------GVLFGKVFSQTTICRFEAL 190

  Fly   278 TLSHNNMIALKPILQAWLEEAEAQAKNKRRDPDAPSVLPAGEKKRKRTSIAAPEKRSLEAYFAVQ 342
            .||..||..|:|:||.|:|||: ..:|.:....|.:::.|  :|||||||....:.:||..|...
Human   191 QLSFKNMCKLRPLLQKWVEEAD-NNENLQEICKAETLVQA--RKRKRTSIENRVRGNLENLFLQC 252

  Fly   343 PRPSGEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR 377
            |:|:.::|:.||::|.|:|:||||||||:|||.||
Human   253 PKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKR 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
acj6	NP_524876.1	POU	222..299	CDD:197673	41/83 (49%)
		Homeodomain	321..377	CDD:459649	29/55 (53%)
POU5F1	NP_002692.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	4..12
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..114
		POU	138..212	CDD:197673	41/79 (52%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P20263	180..186		4/5 (80%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P20263	193..196		1/2 (50%)
		Homeodomain	231..287	CDD:459649	29/55 (53%)