DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment acj6 and POU3F3

DIOPT Version :9

Sequence 1:	NP_524876.1	Gene:	acj6 / 47080	FlyBaseID:	FBgn0000028	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_006227.1	Gene:	POU3F3 / 5455	HGNCID:	9216	Length:	500	Species:	Homo sapiens

Alignment Length:	303	Identity:	114/303 - (37%)
Similarity:	154/303 - (50%)	Gaps:	49/303 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 HHHSMSGPPQRPLQENPFSRQMHHSMDQLDMLDP----------TGSMTTLAP---ISESPLTPT 169
            |..||:|..|.|.|...:|:....:::.:....|          .|:.:.:.|   ..::|....
Human   205 HLPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAE 269

  Fly   170 HQHLHGSYHSMNHMMSHHHPGTLSGHTGGHHGHSAVHHPVITAAVAAAGL-----HPDTDTDPR- 228
            |.| |..:|:..|....||......|.||..|             |..||     |.|.||...
Human   270 HHH-HHHHHAHPHPPHPHHAQGPPHHGGGGGG-------------AGPGLNSHDPHSDEDTPTSD 320

  Fly   229 ELEAFAERFKQRRIKLGVTQADVGKALANLKLPGVGALSQSTICRFESLTLSHNNMIALKPILQA 293
            :||.||::|||||||||.||||||.||..|.   ....||:||||||:|.||..||..|||:|..
Human   321 DLEQFAKQFKQRRIKLGFTQADVGLALGTLY---GNVFSQTTICRFEALQLSFKNMCKLKPLLNK 382

  Fly   294 WLEEAEAQAKNKRRDPDAPSVLPA-GEKKRKRTSIAAPEKRSLEAYFAVQPRPSGEKIAAIAEKL 357
            |||||::...:    |.:...:.| |.|::|||||....|.:||::|...|:||.::|..:|:.|
Human   383 WLEEADSSTGS----PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSL 443

  Fly   358 DLKKNVVRVWFCNQRQKQKRI----VSSVTP----SMTGHGSA 392
            .|:|.||||||||:|||:||:    :...||    |..|..||
Human   444 QLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSA 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acj6	NP_524876.1	POU	222..299	CDD:197673	46/77 (60%)
acj6	NP_524876.1	Homeobox	323..377	CDD:395001	28/53 (53%)
POU3F3	NP_006227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..190
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..319		22/101 (22%)
		POU	314..388	CDD:197673	45/76 (59%)
		Homeobox	409..463	CDD:395001	28/53 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..500		8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156618
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740