DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment acj6 and POU3F1

DIOPT Version :9

Sequence 1:	NP_524876.1	Gene:	acj6 / 47080	FlyBaseID:	FBgn0000028	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_002690.3	Gene:	POU3F1 / 5453	HGNCID:	9214	Length:	451	Species:	Homo sapiens

Alignment Length:	259	Identity:	104/259 - (40%)
Similarity:	139/259 - (53%)	Gaps:	41/259 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 MHHSMDQLDMLDPTGSMTTLAPISESPLTPTHQHLHGSYHSMNHMMSHHHPGTLSGHTGGHHGHS 203
            :||::.:      .|....|.|   ||  |.|...||  |:..|           .|.||.|..:
Human   187 LHHALHE------DGHEAQLEP---SP--PPHLGAHG--HAHGH-----------AHAGGLHAAA 227

  Fly   204 AVHHPVITAAVAAAGLHPDTDT-DPRELEAFAERFKQRRIKLGVTQADVGKALANLKLPGVGALS 267
            |..||......::.|.|.|.|. ...:||.||::|||||||||.||||||.||..|.   ....|
Human   228 AHLHPGAGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLY---GNVFS 289

  Fly   268 QSTICRFESLTLSHNNMIALKPILQAWLEEAEAQAKNKRRDPDAPSVLPAGEKKRKRTSIAAPEK 332
            |:||||||:|.||..||..|||:|..||||.::.:.:   ..:...:...|.|::|||||....|
Human   290 QTTICRFEALQLSFKNMCKLKPLLNKWLEETDSSSGS---PTNLDKIAAQGRKRKKRTSIEVGVK 351

  Fly   333 RSLEAYFAVQPRPSGEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRIVSSVTPSMTGHGSAGFGY 396
            .:||::|...|:||..:|..:|:.|.|:|.||||||||:|||:||    :||      :||.|:
Human   352 GALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKR----MTP------AAGAGH 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acj6	NP_524876.1	POU	222..299	CDD:197673	45/77 (58%)
acj6	NP_524876.1	Homeobox	323..377	CDD:395001	28/53 (53%)
POU3F1	NP_002690.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..154
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..253		24/89 (27%)
		POU	247..321	CDD:197673	44/76 (58%)
		Homeobox	342..396	CDD:395001	28/53 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..451		7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156608
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740