DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment acj6 and ONECUT1

DIOPT Version :9

Sequence 1:	NP_524876.1	Gene:	acj6 / 47080	FlyBaseID:	FBgn0000028	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_004489.1	Gene:	ONECUT1 / 3175	HGNCID:	8138	Length:	465	Species:	Homo sapiens

Alignment Length:	406	Identity:	78/406 - (19%)
Similarity:	128/406 - (31%)	Gaps:	182/406 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 YHH------HSMSGP-------------------------PQRPLQ-----ENPFSRQMHH---- 141
            |||      ||::||                         |.:||.     .:.|....||
Human    68 YHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSDKFPHHHHHHHHH 132

  Fly   142 ---------------------------SMDQLDM---LDPTGSMTTLAPISESPLTPTHQHLHGS 176
                                       ||:.|..   .|..|...:|:|:|.|.|        ||
Human   133 HHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPLSSSGL--------GS 189

  Fly   177 YHSMNHMMSH---------------------HHPGTLSGH--------TGG---------HHGHS 203
            .|:....:.|                     |||..|..|        :.|         ||.|:
Human   190 IHNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHA 254

  Fly   204 AVH--------------HPVITAAVAAAGLHPDTDTDPRELEAFAERFKQRRIKLGVTQADVGKA 254
            .::              :|.:|.|..:.|      ::..::|....:...:||...:.:..:.:|
Human   255 HLNAQGHGQLLGTAREPNPSVTGAQVSNG------SNSGQMEEINTKEVAQRITTELKRYSIPQA 313

  Fly   255 LANLKLPGVGALSQSTICRFESLTLSHNNMIALKP------------ILQAWLEEAEAQ------ 301
            :          .:|..:||.:. ||| :.:...||            .:..||:|.|.|
Human   314 I----------FAQRVLCRSQG-TLS-DLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALR 366

  Fly   302 -AKNKRRDPD-------APSVLPAGEKKRKRTSIAAPEKRSLEAYFAVQPRPSGEKIAAIAEKLD 358
             |..||::.:       .|        |:.|......::|:|.|.|....|||.|....|:::|.
Human   367 LAACKRKEQEHGKDRGNTP--------KKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLG 423

  Fly   359 LKKNVVRVWFCNQRQK 374
            |:.:.|..:|.|.|::
Human   424 LELSTVSNFFMNARRR 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acj6	NP_524876.1	POU	222..299	CDD:197673	15/88 (17%)
acj6	NP_524876.1	Homeobox	323..377	CDD:395001	16/52 (31%)
ONECUT1	NP_004489.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..141		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..290		4/31 (13%)
		CUT	290..362	CDD:396794	17/83 (20%)
		HOX	385..440	CDD:197696	18/63 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..465
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910