DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment acj6 and pou3f2b

DIOPT Version :9

Sequence 1:	NP_524876.1	Gene:	acj6 / 47080	FlyBaseID:	FBgn0000028	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_571235.1	Gene:	pou3f2b / 30397	ZFINID:	ZDB-GENE-980526-370	Length:	378	Species:	Danio rerio

Alignment Length:	372	Identity:	131/372 - (35%)
Similarity:	178/372 - (47%)	Gaps:	61/372 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 NPSIHISSSCDSLESRLLEDA-SLLCNSWSARQNGDIFAGINDGI--LSRAEA-------LAAVD 94
            :|||..|......::....|| :||.:.:|.:.|....:..:..|  ||..|.       |...|
Zfish    15 SPSIVHSEPGSMQQATAYRDAQTLLQSDYSLQSNSHPLSHAHQWITALSHGEGGPWSSSPLGEQD 79

  Fly    95 I---------QKHQAQHV-HSQMPSQIKHDVMYHHHSMSGPPQRPLQENPFSRQMHHSMDQ-LDM 148
            |         :.|.:.:: |...|..:.|....:||.............|   .|..|..| |..
Zfish    80 IKPAVQSPRDEMHNSSNLQHQSRPPHLVHQTHGNHHDSRAWRTTTAAHIP---SMATSNGQSLIY 141

  Fly   149 LDPTGSMTTLAPISESPLTPTHQHLHGSYHSMNHMMSHHHPGTLS--GHTGGHHGHSA--VHHPV 209
            ..|:.|:..|.|.|       .|.:|  :|||......||...||  ||....|.|.:  .||.
Zfish   142 SQPSFSVNGLIPGS-------GQGIH--HHSMRDAHEDHHSPHLSDHGHPPSQHQHQSHQSHHD- 196

  Fly   210 ITAAVAAAGLHPDTDTDPR-ELEAFAERFKQRRIKLGVTQADVGKALANLKLPGVGALSQSTICR 273
                      |.|.||... :||.||::|||||||||.||||||.||..|.   ....||:||||
Zfish   197 ----------HSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLY---GNVFSQTTICR 248

  Fly   274 FESLTLSHNNMIALKPILQAWLEEAEAQAKNKRRDPDAPSVLPA-GEKKRKRTSIAAPEKRSLEA 337
            ||:|.||..||..|||:|..|||||::.:.:    |.:...:.| |.|::|||||....|.:||:
Zfish   249 FEALQLSFKNMCKLKPLLNKWLEEADSTSGS----PTSLDKIAAQGRKRKKRTSIEVSVKGALES 309

  Fly   338 YFAVQPRPSGEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRIVSSVTP 384
            :|...|:|:..:|.::|:.|.|:|.||||||||:|||:||    :||
Zfish   310 HFLKCPKPAASEITSLADSLQLEKEVVRVWFCNRRQKEKR----MTP 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acj6	NP_524876.1	POU	222..299	CDD:197673	46/77 (60%)
acj6	NP_524876.1	Homeobox	323..377	CDD:395001	27/53 (51%)
pou3f2b	NP_571235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..118		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..205		22/73 (30%)
		POU	200..274	CDD:197673	45/76 (59%)
		Homeobox	295..348	CDD:278475	27/52 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..378		4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592228
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740