DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment acj6 and pou3f3b

DIOPT Version :9

Sequence 1:	NP_524876.1	Gene:	acj6 / 47080	FlyBaseID:	FBgn0000028	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_958855.2	Gene:	pou3f3b / 30321	ZFINID:	ZDB-GENE-980526-140	Length:	443	Species:	Danio rerio

Alignment Length:	366	Identity:	130/366 - (35%)
Similarity:	173/366 - (47%)	Gaps:	64/366 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SARQNGDIFAGINDGILS---RAEALAAVDIQKHQAQHVHSQMPSQIKHDVMYHHHSMSGPPQRP 129
            :|...|.:.:..:..:.|   .|.|.||..:...:|....|..|.           .|:|.||:.
Zfish    63 AASNGGHMLSHAHQWVTSLPHAAAAAAAAAVAAAEAGSPWSSSPV-----------GMTGSPQQQ 116

  Fly   130 LQENPFSRQMHHSMDQLDMLDP-----------TGSMTTLAPISESPLTPTHQHLHGSYHS---- 179
            ..:|...|...||...|....|           .|| ||.|.|..  ||.:.|......:|
Zfish   117 DVKNNSGRDDLHSGTALHHRAPHLGPHQTHAGAWGS-TTAAHIPS--LTGSQQQQQSLIYSQPGG 178

  Fly   180 --MNHMMSHH------HPGTLSGHT--------GGHHGHSAVHHPVITAAVAAAGLHPDTDTDPR 228
              :|.|:|..      |||.:.|.|        ..||.|...||......|.:...|.|.||...
Zfish   179 FTVNGMLSPPGSQSLVHPGLVRGDTPELDHSSHHHHHHHQHQHHQQAHHGVNSHDPHSDEDTPTS 243

  Fly   229 -ELEAFAERFKQRRIKLGVTQADVGKALANLKLPGVGALSQSTICRFESLTLSHNNMIALKPILQ 292
             :||.||::|||||||||.||||||.||..|.   ....||:||||||:|.||..||..|||:|.
Zfish   244 DDLEHFAKQFKQRRIKLGFTQADVGLALGTLY---GNVFSQTTICRFEALQLSFKNMCKLKPLLN 305

  Fly   293 AWLEEAEAQAKNKRRDPDAPSVLPA-GEKKRKRTSIAAPEKRSLEAYFAVQPRPSGEKIAAIAEK 356
            .|||||::...:    |.:...:.| |.|::|||||....|.:||::|...|:||.::|.::|:.
Zfish   306 KWLEEADSSTGS----PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADN 366

  Fly   357 LDLKKNVVRVWFCNQRQKQKRIVSSVTP-------SMTGHG 390
            |.|:|.||||||||:|||:||:.....|       |..|:|
Zfish   367 LQLEKEVVRVWFCNRRQKEKRMTPPGVPQTPEDVYSQVGNG 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acj6	NP_524876.1	POU	222..299	CDD:197673	46/77 (60%)
acj6	NP_524876.1	Homeobox	323..377	CDD:395001	28/53 (53%)
pou3f3b	NP_958855.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..150		12/60 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..244		18/61 (30%)
		POU	238..312	CDD:197673	45/76 (59%)
		Homeobox	333..386	CDD:278475	28/52 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740