DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment acj6 and Pou4f2

DIOPT Version :9

Sequence 1:	NP_524876.1	Gene:	acj6 / 47080	FlyBaseID:	FBgn0000028	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_620394.2	Gene:	Pou4f2 / 18997	MGIID:	102524	Length:	411	Species:	Mus musculus

Alignment Length:	404	Identity:	195/404 - (48%)
Similarity:	220/404 - (54%)	Gaps:	112/404 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GRYSPSYRS----------SEQMRR-CMPNPSIHISSSCDSLESRLLEDASLLCNSWSARQNGDI 75
            ||.|.|..|          ||.||| |:|.|.                              .:|
Mouse    67 GRSSSSSSSGSGGSGGGGGSEAMRRACLPTPP------------------------------SNI 101

  Fly    76 FAGINDGILSRAEALAAVDIQKHQAQHVHSQMPSQIKHDVMYHHHSMSGPPQRPLQENPFSRQ-M 139
            |.|:::.:|:||||||||||......|               |||    ||    ..:||... .
Mouse   102 FGGLDESLLARAEALAAVDIVSQSKSH---------------HHH----PP----HHSPFKPDAT 143

  Fly   140 HHSMDQLDMLDPTGSMTTLAPISE-SPLTPTHQHLHGSYHSMNHMMSHHH--------------- 188
            :|:|:.:.......|.:  .|||. |.|..||.|.|..:|       |||
Mouse   144 YHTMNTIPCTSAASSSS--VPISHPSALAGTHHHHHHHHH-------HHHQPHQALEGELLEHLS 199

  Fly   189 PGTLSGHTGG----------HHGHSAVHHPVITAAVAAAGLH---------PDTDTDPRELEAFA 234
            ||...|...|          |..|.|..:|:..||::.|..|         .|.|.|||:|||||
Mouse   200 PGLALGAMAGPDGTVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFA 264

  Fly   235 ERFKQRRIKLGVTQADVGKALANLKLPGVGALSQSTICRFESLTLSHNNMIALKPILQAWLEEAE 299
            ||||||||||||||||||.||||||:||||:||||||||||||||||||||||||||||||||||
Mouse   265 ERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAE 329

  Fly   300 AQAKNKRRDPDAPSVLPAGEKKRKRTSIAAPEKRSLEAYFAVQPRPSGEKIAAIAEKLDLKKNVV 364
               |:.|.....|.:....||||||||||||||||||||||:|||||.|||||||||||||||||
Mouse   330 ---KSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVV 391

  Fly   365 RVWFCNQRQKQKRI 378
            |||||||||||||:
Mouse   392 RVWFCNQRQKQKRM 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acj6	NP_524876.1	POU	222..299	CDD:197673	70/76 (92%)
acj6	NP_524876.1	Homeobox	323..377	CDD:395001	51/53 (96%)
Pou4f2	NP_620394.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..95		11/27 (41%)
		Required for transcriptional activation. /evidence=ECO:0000269\|PubMed:15733064	93..239		51/207 (25%)
		POU-IV box	112..121		8/8 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..190		14/44 (32%)
		Nuclear speckle targeting signal. /evidence=ECO:0000250\|UniProtKB:Q12837	173..187		7/20 (35%)
		Required for DNA-binding and transcriptional repression. /evidence=ECO:0000269\|PubMed:15733064, ECO:0000269\|PubMed:7852360	240..411		133/169 (79%)
		POU	252..329	CDD:197673	70/76 (92%)
		Homeobox	350..403	CDD:278475	50/52 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847017
Domainoid	1	1.000	141	1.000	Domainoid score	I4697
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001337
OrthoInspector	1	1.000	-	-		otm44195
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2889
SonicParanoid	1	1.000	-	-		X830
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830