DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment acj6 and POU5F2

DIOPT Version :9

Sequence 1:	NP_524876.1	Gene:	acj6 / 47080	FlyBaseID:	FBgn0000028	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_694948.1	Gene:	POU5F2 / 134187	HGNCID:	26367	Length:	328	Species:	Homo sapiens

Alignment Length:	165	Identity:	65/165 - (39%)
Similarity:	95/165 - (57%)	Gaps:	22/165 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 RELEAFAERFKQRRIKLGVTQADVGKALANLKLPGVGA-----LSQSTICRFESLTLSHNNMIAL 287
            :||:..|:..:|:|:.||.:|||||.|        |||     |||:||||||:..||..||..|
Human   124 KELQQLAKELRQKRLSLGYSQADVGIA--------VGALFGKVLSQTTICRFEAQQLSVANMWKL 180

  Fly   288 KPILQAWLEEAEAQAKNKRRDPDAPSVLPAGEKKRKRTSIAAPEKR---SLEAYFAVQPRPSGEK 349
            :|:|:.||:|.||:  |.........:|....|.|:    |:.|:|   |||.:|...|:|:.::
Human   181 RPLLKKWLKEVEAE--NLLGLCKMEMILQQSGKWRR----ASRERRIGNSLEKFFQRCPKPTPQQ 239

  Fly   350 IAAIAEKLDLKKNVVRVWFCNQRQKQKRIVSSVTP 384
            |:.||..|.|:|:||||||.|:.:...|..:..:|
Human   240 ISHIAGCLQLQKDVVRVWFYNRSKMGSRPTNDASP 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acj6	NP_524876.1	POU	222..299	CDD:197673	35/75 (47%)
acj6	NP_524876.1	Homeobox	323..377	CDD:395001	22/56 (39%)
POU5F2	NP_694948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Pou	124..192	CDD:278582	35/75 (47%)
		Homeobox	<225..261	CDD:278475	17/35 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840