DRSC/TRiP Functional Genomics Resources

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Protein Alignment NCL and PAB1

DIOPT Version :9

Sequence 1:NP_005372.2 Gene:NCL / 4691 HGNCID:7667 Length:710 Species:Homo sapiens
Sequence 2:NP_011092.1 Gene:PAB1 / 856912 SGDID:S000000967 Length:577 Species:Saccharomyces cerevisiae


Alignment Length:374 Identity:94/374 - (25%)
Similarity:166/374 - (44%) Gaps:49/374 - (13%)


- Green bases have known domain annotations that are detailed below.


Human   286 KQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDL-----AVVDVRIGM 345
            :::||..::.|.||    .::.:|:||:|..:.|...|....|.:.:.:.:     |:....:| 
Yeast    21 QKQAATGSESQSVE----NSSASLYVGDLEPSVSEAHLYDIFSPIGSVSSIRVCRDAITKTSLG- 80

Human   346 TRKFGYVDFESAEDLEKALE-LTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDEL 409
               :.||:|...|...||:| |....:.|...::...:...|.:::.:..:..|||...:....|
Yeast    81 ---YAYVNFNDHEAGRKAIEQLNYTPIKGRLCRIMWSQRDPSLRKKGSGNIFIKNLHPDIDNKAL 142

Human   410 KEVFEDAAEIRLVSK-----DGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQ 469
            .:.|....:| |.||     :|||||..::.|:.|..|::..:...|..::|:.|  |......:
Yeast   143 YDTFSVFGDI-LSSKIATDENGKSKGFGFVHFEEEGAAKEAIDALNGMLLNGQEI--YVAPHLSR 204

Human   470 NQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEK---ATFIKVPQNQNGKSKGYAFIEFA 531
            .:  |..:..........|.:.|::...|:|..||:|.|   .....:.::.:||.||:.|:.:.
Yeast   205 KE--RDSQLEETKAHYTNLYVKNINSETTDEQFQELFAKFGPIVSASLEKDADGKLKGFGFVNYE 267

Human   532 SFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSK-----------------TLFVKGL 579
            ..|||.:|:.:.|..|:.|..:.:   |.....|.|....|                 .||||.|
Yeast   268 KHEDAVKAVEALNDSELNGEKLYV---GRAQKKNERMHVLKKQYEAYRLEKMAKYQGVNLFVKNL 329

Human   580 SEDTTEETLKESFD--GSVRARIVTDRETGSSKGFGFVDFNSEEDAKAA 626
            .:...:|.|:|.|.  |::.:..|...|.|.|||||||.|::.|:|..|
Yeast   330 DDSVDDEKLEEEFAPYGTITSAKVMRTENGKSKGFGFVCFSTPEEATKA 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NCLNP_005372.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..303 5/16 (31%)
8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X 58..135
RRM1_NCL 307..381 CDD:240849 18/79 (23%)
RRM 379..628 CDD:223796 71/275 (26%)
RRM2_NCL 390..465 CDD:240850 21/79 (27%)
RRM3_NCL 485..557 CDD:240851 20/74 (27%)
RRM4_NCL 572..649 CDD:240852 25/74 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..710
PAB1NP_011092.1 PABP-1234 38..559 CDD:130689 89/353 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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