DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCL and gar2

DIOPT Version :9

Sequence 1:	NP_005372.2	Gene:	NCL / 4691	HGNCID:	7667	Length:	710	Species:	Homo sapiens
Sequence 2:	NP_593531.1	Gene:	gar2 / 2542869	PomBaseID:	SPAC140.02	Length:	500	Species:	Schizosaccharomyces pombe

Alignment Length:	688	Identity:	181/688 - (26%)
Similarity:	267/688 - (38%)	Gaps:	218/688 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    51 KKGKKAAATSAKK-VVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATP 114
            ||.|    ||.|| |..:.:||.|:..|:|...:|  |:||...||::   :|...:|.|.....
pombe     3 KKDK----TSVKKSVKETASKKGAIEKPSKSKKIT--KEAAKEIAKQS---SKTDVSPKKSKKEA 58

Human   115 GKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAA 179
            .:|....|.||..      .|..|:.|||:|..|.:.:|...|.:....:.:....|..:..:.:
pombe    59 KRASSPEPSKKSV------KKQKKSKKKEESSSESESESSSSESESSSSESESSSSESESSSSES 117

Human   180 AAPASEDE----DDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEE 240
            ::..||:|    .:|..|...:.....|.:.||||             ||.:           ||
pombe   118 SSSESEEEVIVKTEEKKESSSESSSSSESEEEEEA-------------VVKI-----------EE 158

Human   241 DDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTT 305
            ..|...|...|....:.:.:....|.|||||.|                  |..::|.||:..::
pombe   159 KKESSSDSSSESSSSESESESSSSESEEEEEVV------------------EKTEEKKEGSSESS 205

Human   306 AFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLK 370
            :                                              |.||:.|....   :|
pombe   206 S----------------------------------------------DSESSSDSSSE---SG-- 219

Human   371 VFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIE 435
                    :.....||:.|..             ::||.|...|.|:|
pombe   220 --------DSDSSSDSESESS-------------SEDEKKRKAEPASE----------------- 246

Human   436 FKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEE 500
               |..|:.|                               |.|..|.|:.|:.:..||::..::
pombe   247 ---ERPAKIT-------------------------------KPSQDSNETCTVFVGRLSWNVDDQ 277

Human   501 TLQEVFEK-ATFI---KVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPR 561
            .|.:.||: .|.:   .:...|:|:||||.:::|.:.|.||.|:.:...:||:||.:.|:|..||
pombe   278 WLGQEFEEYGTIVGARVIMDGQSGRSKGYGYVDFETPEAAKAAVAANGTKEIDGRMVNLDLSNPR 342

Human   562 GS---PNAR----------SQPSKTLFVKGLSEDTTEETLKESFDG-----SVRARIVTDRETGS 608
            .:   |.|:          |:||.|:||..||.:.||:.|..:|.|     |:  |:.||.::|.
pombe   343 PANPQPYAQQRAGNFGDQLSEPSDTVFVGNLSFNATEDDLSTAFGGCGDIQSI--RLPTDPQSGR 405

Human   609 SKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGR 673
            .||||:|.|:..:.||...| |....|.|....||::.|:..   ||..||||||||| ||.|||
pombe   406 LKGFGYVTFSDIDSAKKCVE-MNGHFIAGRPCRLDFSTPRTG---GGSRGGRGGFGGR-GGFGGR 465

Human   674 GGFGGRGRGGFGGRGGFRGGRGGGGDHKP-QGKKTKFE 710
            ||||| |||  .||||.|.|....|...| .|.|..|:
pombe   466 GGFGG-GRG--RGRGGARSGNPNRGSVAPFSGNKVTFD 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCL	NP_005372.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..303		64/256 (25%)
		8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135		23/77 (30%)
		RRM1_NCL	307..381	CDD:240849	5/73 (7%)
		RRM	379..628	CDD:223796	70/270 (26%)
		RRM2_NCL	390..465	CDD:240850	9/74 (12%)
		RRM3_NCL	485..557	CDD:240851	23/75 (31%)
		RRM4_NCL	572..649	CDD:240852	30/81 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..710		37/70 (53%)
gar2	NP_593531.1	RRM1_gar2	264..339	CDD:240893	23/74 (31%)
gar2	NP_593531.1	RRM2_gar2	368..439	CDD:240894	26/73 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I1489
OMA	1	1.010	-	-		QHG57760
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.970