DRSC/TRiP Functional Genomics Resources

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Protein Alignment NCK1 and NBP2

DIOPT Version :10

Sequence 1:NP_006144.1 Gene:NCK1 / 4690 HGNCID:7664 Length:377 Species:Homo sapiens
Sequence 2:NP_010446.3 Gene:NBP2 / 851740 SGDID:S000002569 Length:236 Species:Saccharomyces cerevisiae


Alignment Length:156 Identity:39/156 - (25%)
Similarity:65/156 - (41%) Gaps:39/156 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    86 VPDSASPAD-----DSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWW- 144
            |.||::..|     .|...|.:  |.:|..|...:::..|.::||.|.:|..|.:..|...||. 
Yeast    87 VSDSSNGEDTYNKRQSITLPDD--YIVNQRAVALYDFEPENDNELRLAEGDIVFISYKHGQGWLV 149

Human   145 ----RGSYNGQVGWFPSNYVT----EEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVV-QALYP 200
                .||..|.|   |..:|:    |:|::              .|.|......:.|:: |::.|
Yeast   150 AENESGSKTGLV---PEEFVSYIQPEDGEN--------------EVENKARPFYLTHLITQSVSP 197

Human   201 ---FSSSNDEEL--NFEKGDVMDVIE 221
               ..::|::|.  |.|..|:.||.|
Yeast   198 KNNIDNTNEDEYDDNDEWEDIDDVAE 223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NCK1NP_006144.1 SH3_Nck1_1 3..61 CDD:212833
SH3_Nck1_2 108..162 CDD:212834 17/62 (27%)
SH3_Nck1_3 193..249 CDD:212837 11/35 (31%)
SH2_Nck1 280..376 CDD:198271
NBP2NP_010446.3 SH3_Nbp2-like 114..168 CDD:212799 16/56 (29%)
Blue background indicates that the domain is not in the aligned region.

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