DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCK1 and nck-1

DIOPT Version :9

Sequence 1:	NP_001278928.1	Gene:	NCK1 / 4690	HGNCID:	7664	Length:	377	Species:	Homo sapiens
Sequence 2:	NP_001361996.1	Gene:	nck-1 / 180690	WormBaseID:	WBGene00006410	Length:	397	Species:	Caenorhabditis elegans

Alignment Length:	423	Identity:	173/423 - (40%)
Similarity:	241/423 - (56%)	Gaps:	83/423 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKA 65
            |:|:.||| |:||:||:||||.|||||||.||||||:||:|.|..|..||||||||      ||.
Worm     1 MSEDYVVV-KYDYLAQEEQELTIKKNERLKLLDDSKNWWKVMNDSNSVGFVPSNYV------RKE 58

Human    66 SIVKNLKDTL-GIGKVKRKPSVPDSASPADDSFVDPGERL-------YDLN-----------MP- 110
            |||...|.|: |:.:.:.:.|.|           :|.|||       :.||           :|
Worm    59 SIVDKAKGTIKGLARGRNRSSDP-----------EPEERLNGIARLAFSLNNNCAVTPSSNKIPM 112

Human   111 ------AYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRG-SYNGQVGWFPSNYVTEEGDSPL 168
                  |.|||.|....||||.|.||..|.|:||.:||||:| :.||.||||||||| ||.::..
Worm   113 MSSKTKAVVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYV-EEVEAST 176

Human   169 GDHVGSLSEK---LAAV------------VNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMD 218
            ..:.||:..:   .|||            :....:...:.||.|||.|.:|:.|||:|:||:.::
Worm   177 NGNQGSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEIQVVVALYSFDASSSEELSFKKGERLE 241

Human   219 VIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT-SGLEPSPPQCDYIRPSLTGKFAGN-- 280
            :::.||:||:||..|..:|..||||:||:.|:.::..: :..:...||           ::||
Worm   242 IVDHPEHDPDWWMARNASGTTGLVPRNYIEVVNDSSSSKASHQDFAPQ-----------YSGNGE 295

Human   281 ------PWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVY 339
                  |||:|:::|.:||..| ..|.||:||:|||||:|.|.|:|::...:|||||||..:.:.
Worm   296 IPMEQQPWYFGRISRERAEDLL-LHGREGEFLVRDSESNPGDLSISMRGIERNKHFKVQNVDGLL 359

Human   340 CIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYL 372
            .||.|.|..|..|:.||..:|||:|.. |||:|
Worm   360 KIGNRTFVDMNALINHYTTSPIFSSPT-EKLFL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCK1	NP_001278928.1	SH3_Nck1_1	3..61	CDD:212833	39/57 (68%)
		SH3_Nck1_2	108..162	CDD:212834	34/72 (47%)
		SH3_Nck1_3	193..249	CDD:212837	27/55 (49%)
		SH2_Nck1	280..376	CDD:198271	46/101 (46%)
nck-1	NP_001361996.1	SH3_Nck_1	5..55	CDD:212699	36/50 (72%)
		SH3_Nck_2	118..171	CDD:212700	32/53 (60%)
		SH3_Nck_3	217..272	CDD:212701	27/54 (50%)
		SH2_Nck_family	301..392	CDD:198196	45/93 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161455351
Domainoid	1	1.000	81	1.000	Domainoid score	I5970
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I1959
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46567
OrthoDB	1	1.010	-	-		D1097449at2759
OrthoFinder	1	1.000	-	-		FOG0002240
OrthoInspector	1	1.000	-	-		otm15398
orthoMCL	1	0.900	-	-		OOG6_106243
Panther	1	1.100	-	-	LDO	PTHR19969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4150
SonicParanoid	1	1.000	-	-		X1672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940