DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM2 and DIP-zeta

DIOPT Version :9

Sequence 1:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens
Sequence 2:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	412	Identity:	98/412 - (23%)
Similarity:	154/412 - (37%)	Gaps:	72/412 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    80 NPQGEKIISTQRV---------------VVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQE 129
            :|.|.|.::|..|               .|...|..|.:...|..|...|       .|...|..
  Fly    48 HPSGSKTVATGVVPNFGGAAGNGAGGGGPVAGSGTGSTVVGSNGVIVAGG-------GANVPTSN 105

Human   130 ATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLY---------HNEEVT---- 181
            ..:|:|   :..|.|.:.......|.:.::.|.|.:..:..|:|::         ||..:|
  Fly   106 LNIVVE---EPEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPR 167

Human   182 -TISDNRFAMLANNNLQILNINKSDEGIYRCE-GRVEARGEIDFRDIIVIVNVPPAISMPQKSFN 244
             :::.::........|.|.|:::.|.|.|.|: ..|.|:.:..:.:::    |||.|.....|.:
  Fly   168 ISVTHDKHDRHRTWYLHINNVHEEDRGRYMCQINTVTAKTQFGYLNVV----VPPNIDDSLSSSD 228

Human   245 ATAERGEEMTFSCRASGSPEPAISWFR-NGKLIEENEKYIL---KGSNTELTVRNIINSDGGPYV 305
            .....|..::..|||||||.|.|.|.| :...|..|:.:|:   :|...|:|  .|...|.|.|:
  Fly   229 VIVREGANISLRCRASGSPRPIIKWKRDDNSRIAINKNHIVNEWEGDTLEIT--RISRLDMGAYL 291

Human   306 CRATN----------KAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWK 360
            |.|:|          |...|    |..:.:.||  ||....  |...||:.|..|..|.....|.
  Fly   292 CIASNGVPPTVSKRIKVSVD----FPPMLLIPH--QLVGAP--EGFNVTIECFTEAHPTSLNYWT 348

Human   361 RAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYA 425
            |.............::..:.:........|.|.:|...|.|.|.|.|.:..|.....:.|.:.|.
  Fly   349 RGEGPIIHDSHKYKVEATVGLPAYKTHMKLTIINVSSGDDGIYKCVAKNPRGETDGIIRLYVSYP 413

Human   426 PKFISNQTIYYS---WEGNPIN 444
            |...|: .||.:   |..|.||
  Fly   414 PTTASS-GIYSTDTHWGENGIN 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	15/71 (21%)
		I-set	47..136	CDD:254352	14/70 (20%)
		I-set	142..218	CDD:254352	18/90 (20%)
		IGc2	153..214	CDD:197706	15/75 (20%)
		Ig	233..326	CDD:299845	32/106 (30%)
		I-set	240..323	CDD:254352	29/96 (30%)
		Ig5_NCAM-2	325..422	CDD:143278	22/96 (23%)
		IG_like	333..420	CDD:214653	17/86 (20%)
		IG_like	438..515	CDD:214653	4/7 (57%)
		IGc2	439..507	CDD:197706	3/6 (50%)
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	17/99 (17%)
		Ig	130..200	CDD:143165	14/69 (20%)
		I-set	226..310	CDD:254352	27/85 (32%)
		IGc2	233..298	CDD:197706	25/66 (38%)
		Ig	313..410	CDD:299845	22/100 (22%)
		IG_like	325..410	CDD:214653	18/86 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910