DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM2 and DIP-theta

DIOPT Version :9

Sequence 1:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens
Sequence 2:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	695	Identity:	149/695 - (21%)
Similarity:	236/695 - (33%)	Gaps:	191/695 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   117 RCQATDAKGQTQEATVVLEIYQKL----TFREVVSPQEFKQGEDAEVVCRVSSSPAPAV------ 171
            |.|...|.|:.|....:.||..:|    ....|||           ::|...:.|..|.
  Fly    18 RRQRRRAAGKLQRKREMPEISSRLIVATATAAVVS-----------IICLSLALPGCAAQESDDE 71

Human   172 SWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDII---VIVNVP 233
            ..|:|.:::            ::..|...|.:|:|..:......|.:.:.:..:.|   .:||..
  Fly    72 GELHHLDQM------------HHQHQDFIIGESEEHDHIAHHLAEMQNKDELLEDIREDTVVNAI 124

Human   234 PAISMPQKSF-----NATAERGEEMTFSCRASGSPEPAISWFR---------NGKLIEENEKYIL 284
            |...:|:  |     |.|.....|....|.........|:|.|         ...:|.:|.:..:
  Fly   125 PEKDLPK--FGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHVITKNHRMSI 187

Human   285 KGSNTE---LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTY---ENGQV 343
            ..:...   |.:|::..||.|.|:|: .|......:..:|.|.|.|.|:.....|..   |...|
  Fly   188 THAEKRAWILRIRDVKESDKGWYMCQ-INTDPMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNV 251

Human   344 TLVCDAEGEPIPEITWKRAVDGFTFTEGDK--SLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCE 406
            ||.|.|.|.|.|.|||:|        ||.:  .|....|....:| |.|.|..|...:.|.|.|.
  Fly   252 TLKCAATGSPTPTITWRR--------EGGELIPLPNGAEAVAYNG-SFLTIAKVNRLNMGAYLCI 307

Human   407 AASRIGGH-QKSMYLDIEYAPK-FISNQTIYYSWEGNPINISCDVKSNPPASIHW-RRDKLVLPA 468
            |::.|... .|.:.|.:.:.|. :|.||.:..:...| |.:.|..::.|.:..:| :.|.:::|.
  Fly   308 ASNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQN-ITLECQSEAYPKSINYWMKNDTIIVPG 371

Human   469 KNTTNLKTYSTGRK--MILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIE 531
            :.... :|:.:|.|  |.|.|......|||.|.|.|.|.:|              .:...:|:..
  Fly   372 ERFVP-ETFESGYKITMRLTIYEVDIQDFGAYRCVAKNSLG--------------DTDGAIKLYH 421

Human   532 LSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLN-------NLEPNTT 589
            :.|||...:.....|...||:    |.||      :...:.:|.......|       |.:.||
  Fly   422 IPQTTTMTTMAPTVSINTVPV----VLVK------YNKEQRYGSSQNSNTNPYNFNPGNSQQNT- 475

Human   590 YEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHG---------------QPSSGKSFKLSIT 639
             :::....|.||.               :.||..::.               ..||..|...|..
  Fly   476 -KLQRGKSNSKGS---------------DQSPSGLNNVFVGATSSLWNSQDHHSSSSSSSSASSR 524

Human   640 KQD----------------DGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYE 688
            .:|                |.||       .|||..|.........:...|.  |:.:|...|:
  Fly   525 GRDHHQQQHHQQQQQNHGSDHGA-------SYRSDGKSPHLTNHDAKSLTDD--LDRMQDLKGW- 579

Human   689 VQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLG 733
                 |:||....|.                    |||..::|:|
  Fly   580 -----ASRLSPISPI--------------------LGLSMILGVG 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	6/19 (32%)
		I-set	47..136	CDD:254352	5/18 (28%)
		I-set	142..218	CDD:254352	13/81 (16%)
		IGc2	153..214	CDD:197706	9/66 (14%)
		Ig	233..326	CDD:299845	22/109 (20%)
		I-set	240..323	CDD:254352	19/99 (19%)
		Ig5_NCAM-2	325..422	CDD:143278	33/102 (32%)
		IG_like	333..420	CDD:214653	29/92 (32%)
		IG_like	438..515	CDD:214653	21/79 (27%)
		IGc2	439..507	CDD:197706	20/70 (29%)
		FN3	521..613	CDD:238020	18/98 (18%)
		fn3	619..703	CDD:278470	21/114 (18%)
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	19/93 (20%)
		IG_like	137..230	CDD:214653	19/93 (20%)
		IG_like	240..324	CDD:214653	30/92 (33%)
		IGc2	247..310	CDD:197706	26/71 (37%)
		Ig	327..419	CDD:299845	25/107 (23%)
		IG_like	343..420	CDD:214653	22/92 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000