DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM2 and Fas2

DIOPT Version :9

Sequence 1:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	892	Identity:	242/892 - (27%)
Similarity:	374/892 - (41%)	Gaps:	112/892 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    44 ALLQVTISLSKVELS-------------------VGESKFFTC-TAIGEPE---SIDWYNPQGEK 85
            |||..:.||  :||:                   ||:....|| ..:.||.   .:.|.:.:...
  Fly    14 ALLLCSCSL--IELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNT 76

Human    86 IIS-----------TQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQK 139
            |:.           |:.:    .|....|.|.:.::|..|.|.|.|:.|..:..|..|.::.|..
  Fly    77 ILPKPNGRNQPPMYTETL----PGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVA 137

Human   140 LTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKS 204
            :|:......|....|:|..|:|.|.:.|.|.:.||.:.:.:.|.:|.  .::..|.|.|.|:.:|
  Fly   138 ITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDK--YVVQTNGLLIRNVQES 200

Human   205 DEGIYRCEGRVEARGEIDFRDIIVIVNV-PPAISMPQKSFNATAERGEEMTFSCRASGSPEPAIS 268
            |||||.|...|...||:..|.|.|.|.: |..||:|.   |..|..|:....:|.|.|.|.|.||
  Fly   201 DEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPT---NLEAVEGKPFAANCTARGKPVPEIS 262

Human   269 WFRNGKL--IEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQ 331
            |.|:...  :...:::.:......:|:.::...|.|.|.|.|.|:||..:::..|.|.|:|.|.:
  Fly   263 WIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYE 327

Human   332 LKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI-------EVKGQHGSSS 389
            |.|.|.....::.:.|.|:|.|.|.||::|......:|.|.:..|.||       |.:|: .:.:
  Fly   328 LYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGE-STGT 391

Human   390 LHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTI--YYSWEGNPINISCDVKSN 452
            |.|.:.:.||.|.|.|.|.::.....|:.::.:|:||.|...:.:  .:|||....|:||.....
  Fly   392 LRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGI 456

Human   453 PPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILAL 517
            |.|:|.|..:...:.....||||...||.:..|.:.|.:...:..|.|.|||..||...:..|..
  Fly   457 PNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKE 521

Human   518 ADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIV--RSHGVQTMVV 580
            |.||......|..:|:.||.......|.:..|:||..|.|..||..:..|...  ||....:..:
  Fly   522 ARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYI 586

Human   581 LNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVR----EPSPPSIHGQPSSGKS-------- 633
            :..|.|.|.|..|.||.|..|.|::. :...|:.|.|    ||.|  :|......|.
  Fly   587 VEGLRPQTEYSFRFAARNQVGLGNWG-VNQQQSTPRRSAPEEPKP--LHNPVQHDKEEPVVVSPY 648

Human   634 ---FKLSITKQDDGGAPILEYIVKYRSKDK-EDQWLEKKVQGNKDHII------LEHLQWTMGYE 688
               |:|......|.|.||..|.:||....| ...|.|.:...|...::      :..|.....|.
  Fly   649 SDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYR 713

Human   689 VQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTDVSCFFIRQ 753
            :::.|.|.:|||.|...........::|:..........|::|:.:..:||:|.|.|:.|.....
  Fly   714 IELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGVLLLLFVVDLLCCITVH 778

Human   754 CGLLMCITRRMCGKKSGSSGKSKEL-EEGKAAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPN 817
            .|::..:.|:  .|:|.|     |: :|.|...|. |.:.|:           .:..|..|.||
  Fly   779 MGVMATMCRK--AKRSPS-----EIDDEAKLGSLY-GWRFPL-----------PYCSGQLVKEP- 823

Human   818 ETTPLTEPEYVAWSAHLCSNGKLPLKEEDGKEALNPETIEIKVSNDI 864
            ..:||..|..|.......|.   ||   |.||.|...|..||.::.|
  Fly   824 PPSPLPLPPPVKLGGSPMST---PL---DEKEPLRTPTGSIKQNSTI 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	25/124 (20%)
		I-set	47..136	CDD:254352	24/122 (20%)
		I-set	142..218	CDD:254352	24/75 (32%)
		IGc2	153..214	CDD:197706	22/60 (37%)
		Ig	233..326	CDD:299845	27/94 (29%)
		I-set	240..323	CDD:254352	22/84 (26%)
		Ig5_NCAM-2	325..422	CDD:143278	30/103 (29%)
		IG_like	333..420	CDD:214653	26/93 (28%)
		IG_like	438..515	CDD:214653	24/76 (32%)
		IGc2	439..507	CDD:197706	21/67 (31%)
		FN3	521..613	CDD:238020	26/93 (28%)
		fn3	619..703	CDD:278470	24/101 (24%)
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	20/97 (21%)
		IG_like	144..226	CDD:214653	29/83 (35%)
		IGc2	152..209	CDD:197706	22/58 (38%)
		I-set	230..319	CDD:254352	26/91 (29%)
		IGc2	243..309	CDD:197706	17/65 (26%)
		IG_like	330..424	CDD:214653	26/94 (28%)
		IGc2	339..412	CDD:197706	23/73 (32%)
		Ig	447..518	CDD:143165	22/70 (31%)
		fn3	534..611	CDD:278470	24/76 (32%)
		FN3	640..735	CDD:238020	21/94 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3062
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		otm41593
orthoMCL	1	0.900	-	-		OOG6_103800
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4566
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.770