DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM1 and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	89/380 - (23%)
Similarity:	144/380 - (37%)	Gaps:	72/380 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    99 TGEDGSESE---ATVNVKIFQKLMF----KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGR 156
            ||.:|:...   :|:|..|.:...|    :|...|    .|.:..:.|.|.:.....:.|.|..:
  Fly    30 TGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVP----AGRNVKLACSVKNLGSYKVAWMHFEQ 90

Human   157 DVILKKDVRFIVLSNN----------------YLQIRGIKKTDEGTYRCE-GRILARGEINFKDI 204
            ..||  .|...|::.|                :|.|..:::.|.|.|.|: ..:.|:.:..|
  Fly    91 SAIL--TVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGF--- 150

Human   205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK-DGEQIEQEEDDEKYIFSDD 268
             |.|.|||.|.......:.....|.:|||.|.|:|.||||:.|.: ||.:|...:..|.:....|
  Fly   151 -VKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETD 214

Human   269 SSQLTIKKVDKNDEAEYICIAENKAGEQ-DATIHLKVFAKPKITYVENQTAMELEEQVTLTCEAS 332
            |  |.::::.:.....|:|||.|..... ...|.:.|...|.:........:.:...:||.|...
  Fly   215 S--LELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIE 277

Human   333 GDPIPSITWRTSTRNISSEEKASWTRPEKQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVV 397
            .:| .|:.:              |||...|.:.....::.                ||:.||
  Fly   278 ANP-TSLNY--------------WTRENDQMITESSKYKT----------------ETIPGH--- 308

Human   398 RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT 452
            .|:.....||:.::|.:|.|.|.|.|.|..|....::.|.:...|..|.|....|
  Fly   309 PSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTT 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	5/18 (28%)
		IG	124..190	CDD:214652	16/81 (20%)
		Ig	211..307	CDD:325142	29/97 (30%)
		Ig	306..438	CDD:325142	26/131 (20%)
		Ig_3	447..519	CDD:316449	2/6 (33%)
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	22/105 (21%)
		Ig	69..139	CDD:143165	15/71 (21%)
		IG_like	165..249	CDD:214653	25/85 (29%)
		IGc2	172..237	CDD:197706	24/66 (36%)
		IG_like	267..348	CDD:214653	24/114 (21%)
		Ig	270..339	CDD:299845	23/102 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910