DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NCAM1 and robo2

DIOPT Version :9

Sequence 1:NP_001229536.1 Gene:NCAM1 / 4684 HGNCID:7656 Length:884 Species:Homo sapiens
Sequence 2:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster


Alignment Length:827 Identity:192/827 - (23%)
Similarity:285/827 - (34%) Gaps:203/827 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    39 FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTL-----------TIYNANIDDAG 92
            |.||..|: ....|.||....|..|           |..|..:           .|::....|||
  Fly   110 FNCQAEGN-PTPTIQWFKDGRELKT-----------DTGSHRIMLPAGGLFFLKVIHSRRESDAG 162

Human    93 IYKCVVTGEDG--SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHK 154
            .|.|....|.|  ....||:.| .|.:..|:..|......:||.|::.|......| |.|.|:..
  Fly   163 TYWCEAKNEFGVARSRNATLQV-A
FLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKN 226

Human   155 GRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPT------ 213
            |:.:.|..:.|..::....|.|:..:::|:|.|:|                |:.||..|      
  Fly   227 GQTLNLVGNKRIRIVDGGNLAIQEARQSDDGRYQC----------------VVKNVVGTRESATA 275

Human   214 ---IQARQNIV----NATANLGQSVTLVCDAEGFPEPTMSW--TKDGEQIEQEEDDEKYIFSDDS 269
               :..|..::    |.||.:|.||...|...|.|.|.:.|  |..|..:...   ..::..|.|
  Fly   276 FLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLR---RVHVLEDRS 337

Human   270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334
              |.:..|...|..||.|.|:|..|...||..|.|.|.||.........:|:.::|...|:|:|.
  Fly   338 --LKLDDVTLEDMGEYTCEADNAVGGITATGILTVHAPPKFVIRPKNQLVEIGDEVLFECQANGH 400

Human   335 PIPSITWRTSTRNISSEEKASWTRPEKQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHM-VVR 398
            |.|::.|       |.|..:|...|                       |:      .||.| |..
  Fly   401 PRPTLYW-------SVEGNSSLLLP-----------------------GY------RDGRMEVTL 429

Human   399 SHARVSSLTLKSIQYTDAGEYI-CTASNTIGQDSQ----SMYLEVQYAPKL--QGPVAVYTWEGN 456
            :....|.|::......|:|:.: |.|.|.:|..|.    |:..:.:..|.:  ||||       |
  Fly   430 TPEGRSVLSIARFAREDSGKVVTCNALN
AVGSVSSRTVVSVDTQFELPPPIIEQGPV-------N 487

Human   457 Q-------VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP-DSENDFGNY 513
            |       |.:.|.....|...:||:.||..:....:..   .|...|..|.::. ....|.|.|
  Fly   488 QTLPVKSIVVLPCRTLGTPVPQVSWYLDGIPIDVQEHER---RNLSDAGALTISDLQRHEDEGLY 549

Human   514 NCTAVNRIGQESLEFILVQADTPSSPSI------------------DQVEPYSSTAQVQFDEPEA 560
            .|.|.||.|:.|....| :.|||::|:|                  ..||...::..:.:.....
  Fly   550 TCVASNRNGKSS
WSGYL-RLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNK 613

Human   561 TGGVPILKYKAE---------WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 616
            .||..::.|..|         |.|||..|.::.:            |..||.|...|...:.|.|
  Fly   614 VGGSSLVGYVIEMFGKNETDGWVAVGTRVQNTTF------------TQTGLLPGVNYFFLIRAEN 666

Human   617 GKGLGEISAASE--------FKTQPVQGEPSAPKLEGQMGEDGN-----SIKVNLIKQDDGGSPI 668
            ..||...|..||        |.:.....|..|..|.|.:.|..|     |..:.|..|...|..:
  Fly   667 SHGLSLPSPMSEPIT
VGTRYFNSGLDLSEARASLLSGDVVELSNASVVDSTSMKLTWQIINGKYV 731

Human   669 RHYLVRYRALSSEWKPEIRLP---SGSDHVMLKSLDWNAEYEVYVVA-----------------E 713
            ..:.|..|.|.:   |.:..|   :.:.:.:|.|...:|.......|                 .
  Fly   732 EGFYVYARQLPN---PIVNNPAPVTSNTNPLLGSTSTSASASASASALISTKPNIAAAGKRDGET 793

Human   714 NQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVL 760
            ||.|  ..|.....|..:...|...|..:|...||.:...|...|::
  Fly   794 NQSG--GGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIV 838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NCAM1NP_001229536.1 Ig1_NCAM-1 20..115 CDD:143273 22/88 (25%)
IG 124..190 CDD:214652 17/66 (26%)
Ig 211..307 CDD:325142 30/110 (27%)
Ig 306..438 CDD:325142 30/137 (22%)
Ig_3 447..519 CDD:316449 19/79 (24%)
FN3 534..631 CDD:238020 29/131 (22%)
fn3 639..720 CDD:306538 21/105 (20%)
Trypan_PARP <792..>864 CDD:330686
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317 22/87 (25%)
I-set 91..184 CDD:254352 21/85 (25%)
I-set 190..279 CDD:254352 23/104 (22%)
Ig2_Robo 193..279 CDD:143201 22/101 (22%)
I-set 283..370 CDD:254352 27/91 (30%)
Ig 300..370 CDD:299845 22/74 (30%)
Ig 388..>457 CDD:299845 22/104 (21%)
I-set 479..561 CDD:254352 24/91 (26%)
Ig 496..561 CDD:143165 18/67 (27%)
FN3 588..681 CDD:238020 23/104 (22%)
FN3 <817..856 CDD:238020 6/22 (27%)
fn3 864..952 CDD:278470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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