DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NCAM1 and Ama

DIOPT Version :9

Sequence 1:NP_001229536.1 Gene:NCAM1 / 4684 HGNCID:7656 Length:884 Species:Homo sapiens
Sequence 2:NP_731114.2 Gene:Ama / 40831 FlyBaseID:FBgn0000071 Length:341 Species:Drosophila melanogaster


Alignment Length:369 Identity:88/369 - (23%)
Similarity:143/369 - (38%) Gaps:91/369 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   207 IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFS----- 266
            :::.|...|..:::|   |::|.||...|..|...:.::||.|.    ..|.|....:.|     
  Fly    29 VLSAPVISQISKDVV---ASVGDSVEFNCTVEEVGQLSVSWAKR----PSESDTNSVVLSMRNIL 86

Human   267 ---DDSSQLT---------------IKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV 313
               |....:|               |:.::.:|...|.|.....|.|: .|..|.:..|......
  Fly    87 SLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEK-VTKKLSLQIKTPPVIA 150

Human   314 EN---QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQEVHAPWNWQVGRQ 375
            ||   .|.:...:.:.|||.|:|.|.|:|:|                               .|:
  Fly   151 ENTPKSTLVTEGQNLELTCHANGFPKPTISW-------------------------------ARE 184

Human   376 KGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ-DSQSMYLEVQ 439
            ......||         ||::..     .:|.::|:...|.|.|.|.|.|..|| |.:.:.:||:
  Fly   185 HNAVMPAG---------GHLLAE-----PTLRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEVE 235

Human   440 YAPKL--QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA----- 497
            :.|::  |.| .:.....:...:.|.|..||:.|:.|.::|..|.||.:.  ::.||.|:     
  Fly   236 FRPQIAVQRP-KIAQMVSHSAELECSVQGYPAPTVVWHKNGVPLQSSRHH--EVANTASSSGTTT 297

Human   498 SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSI 541
            |.|.:....|.|||:|.|.|.|::|.......|.|...| .||:
  Fly   298 SVLRIDSVGEEDFGDYYCNATNKLGHADARLHLFQTVIP-VPSL 340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NCAM1NP_001229536.1 Ig1_NCAM-1 20..115 CDD:143273
IG 124..190 CDD:214652
Ig 211..307 CDD:325142 25/118 (21%)
Ig 306..438 CDD:325142 29/135 (21%)
Ig_3 447..519 CDD:316449 23/76 (30%)
FN3 534..631 CDD:238020 3/8 (38%)
fn3 639..720 CDD:306538
Trypan_PARP <792..>864 CDD:330686
AmaNP_731114.2 I-set 33..143 CDD:254352 25/117 (21%)
Ig 37..127 CDD:299845 20/96 (21%)
IG_like 154..234 CDD:214653 26/124 (21%)
IGc2 161..223 CDD:197706 22/106 (21%)
I-set 254..330 CDD:254352 24/77 (31%)
IGc2 254..322 CDD:197706 23/69 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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