DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM1 and dpr16

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001287169.1	Gene:	dpr16 / 40619	FlyBaseID:	FBgn0037295	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	326	Identity:	66/326 - (20%)
Similarity:	102/326 - (31%)	Gaps:	99/326 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTP-------NQQRISVVWNDDSS 78
            |:.:.|....:..|:..:..|:: .....|.:||.....|.:..       |..|.:.:.   .|
  Fly   200 QLSLPPLNATVQAGQHAYLPCKL-NQHSGKPLSWVRLRDEHIIAVDHTTFINDARFASLL---QS 260

Human    79 STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVS 143
            :|||             .:|:|  |:.|.....|...........|..||  .|..:
  Fly   261 TTLT-------------TLVSG--GALSTTATPVAALGNSFAHAVPGGQE--RGNSS-------- 300

Human   144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIV 208
                ::.|.                     |||:.:...|.|.|.|:  :....:::.| :|:.|
  Fly   301 ----SLSWT---------------------LQIKYVNLEDAGWYECQ--LATEPKMSAK-VQLFV 337

Human   209 NVPPT--IQARQNIVNATANLGQSVTLVCDAEGFPEPT--MSWTKDGEQIEQEEDD--------- 260
            ..|.|  |..||..|.|    |..|.|.|...|..|..  :.|.:..:|:..|.:.
  Fly   338 ITPRTELIGDRQRFVKA----GSRVELHCIVRGTLEAPKYIFWYRGDQQVTAENEASGAQSGWYT 398

Human   261 --EKYIFSDDS------SQLTIKKVDKNDEAEYICIAENKA----------GEQDATIHLKVFAK 307
              ::.||....      ..|.|..|.|.....|.|..||.|          ||..|:......|:
  Fly   399 QIDRNIFGSTEHNRNTIGSLVIPLVRKIHSGNYTCEPENSAAASMQLHVLSGEYSASAIKSTAAR 463

Human   308 P 308
            |
  Fly   464 P 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	19/100 (19%)
		IG	124..190	CDD:214652	11/65 (17%)
		Ig	211..307	CDD:325142	30/126 (24%)
		Ig	306..438	CDD:325142	2/3 (67%)
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
dpr16	NP_001287169.1	IG_like	205..337	CDD:214653	32/188 (17%)
		Ig	<298..338	CDD:299845	10/75 (13%)
		IG_like	352..447	CDD:214653	22/98 (22%)
		Ig	358..439	CDD:143165	18/80 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810