DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM1 and dpr10

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	88/475 - (18%)
Similarity:	147/475 - (30%)	Gaps:	188/475 - (39%)

- Green bases have known domain annotations that are detailed below.

Human   132 GEDAVIVCDVVSSLPPTIIW-KHKGRDVI------LKKDVRFIVLSNNY--------LQIRGIKK 181
            |:.|.:.|.|......|:.| :|:...::      ...|.||   ..:|        |||:..::
  Fly    68 GKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRF---QTSYHRDIDEWTLQIKWAQQ 129

Human   182 TDEGTYRCEGRILARGEINFKDIQVIVNVPP--TIQARQNIVNATANLGQSVTLVCDAEGFPEPT 244
            .|.|.|.|:                 ::..|  :.....|||:           :.|||
  Fly   130 RDAGVYECQ-----------------ISTQPVRSYSVNLNIVD-----------LIDAE------ 160

Human   245 MSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENK----AGEQDATIH--LK 303
               |.|                       |.:...||:|.|  ||||:    :.::.|.:.  ::
  Fly   161 ---TSD-----------------------IMQQYYNDDAFY--IAENRVYQSSNDEFAGMFGPIQ 197

Human   304 VFAKPKIT-------YVENQTAMELEEQVTLTC--EASGDPIPSITWRTSTRNISSEEKASWTRP 359
            ..|.|..|       ||:..:.      :.|||  :.|.:|...|.|....:.:|.|...
  Fly   198 TVAVPTATILGGPDLYVDKGST------INLTCIIKFSPEPPTHIFWYHQDKVLSEETSG----- 251

Human   360 EKQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 424
                         ||.|                 ...::|....|.|.:.......:|:|.|..|
  Fly   252 -------------GRLK-----------------FKTIKSEETKSILLIYDADLLHSGKYSCYPS 286

Human   425 NT--------IGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLL 481
            ||        :.|..:...::...||   ..||:..|       :|.   :..||
  Fly   287 NTEIASIRVHVLQGERPEAMQTNAAP---AAVALACW-------SCH---FGQAT---------- 328

Human   482 PSSNYSNIKIYNTPSASYLEVTPDSE---NDFGNYNC-----------TAVNRIGQESLEFILVQ 532
                 ..:::.:|..|:.:.:...|.   ...|...|           |.|..|.::.|...|:.
  Fly   329 -----QAVRVISTMVAALVLLEACSSLLLQSGGGGGCPGGGSPAGGMPTRVREIREKPLTNSLLD 388

Human   533 ADTPSSPSIDQVEPYSSTAQ 552
            ...||:.|.::|...|..|:
  Fly   389 PKIPSTTSAERVNNGSRNAR 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	17/72 (24%)
		Ig	211..307	CDD:325142	19/103 (18%)
		Ig	306..438	CDD:325142	27/148 (18%)
		Ig_3	447..519	CDD:316449	12/85 (14%)
		FN3	534..631	CDD:238020	6/19 (32%)
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
dpr10	NP_729591.1	Ig	63..143	CDD:299845	18/94 (19%)
		IG_like	210..297	CDD:214653	23/127 (18%)
		IGc2	217..287	CDD:197706	18/110 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810