DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM1 and dpr13

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	95/435 - (21%)
Similarity:	151/435 - (34%)	Gaps:	110/435 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   185 GTYRCE-GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANL----GQSV--TLVCDAEGFPE 242
            |.||.: ||:|.|.:.....|.:|..:     |...|.:.||:.    |::|  |:...|.   |
  Fly     6 GLYRIKNGRVLDRLQKPAALIFIIAYI-----AACGICDHTASASPGGGKTVAATMTTPAS---E 62

Human   243 PT---------MSWTKDGEQIEQEE-----------------DDEKYIFSDDSSQLT---IKKVD 278
            |:         ||.:|:||.:...:                 |....|  |..||.|   :::..
  Fly    63 PSVRHINQNLIMSQSKEGEPVPVPQPYAQSAASAGGSSITSFDSTNVI--DGQSQPTPTHLQEAV 125

Human   279 KNDEAEYICIAENKAGEQDATIHL-------------------KVFAKPKITYVENQTAMELEEQ 324
            ....:.....|::.||.....:|.                   .:|..|.....||.|.  :..|
  Fly   126 LQTHSHSRIQAKDTAGPYPIPVHRPEPVENHLEANNGIEGGMESLFGTPMYFGTENSTV--VTTQ 188

Human   325 VTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQEVHAPWNWQVGRQKGQAGSAGFPGSHE 389
            :..|..     :|      .|.:...|...||.|  |::.|.   ..||... .:....|..:|
  Fly   189 IGATAH-----VP------CTVHHIGEGVVSWIR--KKDYHL---LTVGLTT-YSSDERFSATH- 235

Human   390 TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLE---VQYAPKLQGPVAVY 451
                    ..|:...:|.:|.:|..|||.|.|..|.   ....|::|.   |:...::.||...|
  Fly   236 --------LKHSEDWTLQIKFVQLRDAGVYECQVST---HPPTSIFLHLSVVEARAEITGPPIRY 289

Human   452 TWEGNQVNITCEVFAYPSAT--ISWFRDGQLLPSSNYS---NIKIYNTP--SASYLEVTPDSEND 509
            ...|:.:.:.|.|.....|:  |.|:.|.:::   ||.   .|.:...|  .:|.|.:.......
  Fly   290 LTPGSTLRLQCRVVQNTEASEYIFWYHDNRMI---NYDIDRGINVSTEPDFQSSELTIQRTRREH 351

Human   510 FGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQ 554
            .||:.|.|.|......|..|. :.|.|::.....|...:.|.|.|
  Fly   352 SGNFTCVASNTQPASVLVHIF-KGDNPAAMYHGHVGGSTKTTQSQ 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	3/4 (75%)
		Ig	211..307	CDD:325142	26/149 (17%)
		Ig	306..438	CDD:325142	30/134 (22%)
		Ig_3	447..519	CDD:316449	19/78 (24%)
		FN3	534..631	CDD:238020	6/21 (29%)
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	29/126 (23%)
		IG_like	182..262	CDD:214653	24/107 (22%)
		IG_like	285..362	CDD:214653	19/79 (24%)
		IGc2	292..361	CDD:197706	17/71 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810