DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM1 and Dscam2

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	1023	Identity:	230/1023 - (22%)
Similarity:	361/1023 - (35%)	Gaps:	277/1023 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    14 LGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKD---KDISWFSPNGEKLTPNQQRISVVWND 75
            |..|..:||:|.|:...:.:|.:..|.|.|..:...   ::|.|:. :|.:| |:..|:
  Fly   325 LTVATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYK-DGRQL-PSSGRV------ 381

Human    76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVK----------------------IFQKL 118
              ..||.:...:.::.|:|:|||...:|...:||..::                      :..|.
  Fly   382 --EDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKC 444

Human   119 MFKNAPTPQ--------------EFREGEDAVIVCDVVS-------------------------- 143
            .....||||              .|..|:...:..||:|
  Fly   445 SAAGNPTPQISWTLDGFPLPSNGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRV 509

Human   144 ---------SLP---------------------------PTIIWKHKGRDVILKKDVRFIVLSNN 172
                     .||                           ..|.|:..||:  |..|:|..|..:.
  Fly   510 QHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRE--LPDDIRQRVQPDG 572

Human   173 YLQIRGIKK-TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ-NIVNATANLGQSVTLVC 235
            .|.|..::| :|.|.|.|..| ..:|....:..:|.|.|||.:...| ||:.  .|:|...:|.|
  Fly   573 SLTISPVQKNSDSGVYTCWAR-NKQGHSARRSGEVTVIVPPKLSPFQTNILQ--LNMGDRASLTC 634

Human   236 D-AEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDAT 299
            . .:|....|::|.|||..|:..:..........:|.|.|:.:..:....|.|:..|.|.|.:.:
  Fly   635 SVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENS 699

Human   300 IHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQEV 364
            ..|.|...|:.........:|....:.|.|:|.|.|.|||.|:.:|.:.|.|.:....||
  Fly   700 QALLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERP----- 759

Human   365 HAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQ 429
                                   ...|.|:         .||.|:.::....|.|:|.|:|.||.
  Fly   760 -----------------------FTKLLGN---------GSLLLQHVKEDREGFYLCQANNGIGT 792

Human   430 D-SQSMYLEVQYAPKLQGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDGQ--LLPSSNYS-NI 489
            . .:.:.|:|..:|...... :|...:|:...:.|.|.......|.|.|.|:  |.||:||. ::
  Fly   793 GIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVWMRSGKNTLNPSTNYKISV 857

Human   490 KIYNTPS--ASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSS-TA 551
            |...||.  ::.|::......|.|.|.|.|.|..|.:.....|...:.|..||:.:....|| :.
  Fly   858 KQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAAMISSRSV 922

Human   552 QVQFDEPEATGGVPILKYKAEWRAVGEEVWHS--------KW--YDAKEASMEGIVTIVGLKPET 606
            .::: :|:..|...:.||..|:|    |..||        :|  .:.|:......: |..|||.|
  Fly   923 NIKW-QPKTLGTGDVTKYIVEFR----EADHSLPPALFVDQWQQIEVKDPPHFNAM-IENLKPAT 981

Human   607 TYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRH- 670
            .||.|:.|....|....|.....:|:|.:  |:.|.|  .:.....|....||........:||
  Fly   982 RYAFRVIAEGSAGRSAPSQELIVRTEPQR--PAGPPL--SLSARPLSSTELLISWVAPLPELRHG 1042

Human   671 ----YLVRYRALSSEWKPEIRLPS-------GSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHF 724
                |.|.|: |||.........|       |:..::|..|...|.|.|.|.|.||.|....
  Fly  1043 DIQGYNVGYK-LSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGPL--- 1103

Human   725 VFRTSAQPTA------IPANGSPTSGLSTGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAV 783
                 ::|||      :|:.  |..                      |:.|..|:...|
  Fly  1104 -----SEPTAAQTMEDVPSR--PPE----------------------DVRCAALSSQSL------ 1133

Human   784 NLCGKAGPGAKGKDMEEG-KAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKG 847
            .:..:..|......:.:| |..|      |||:     ::..|:.|   ..|..:||.||....|
  Fly  1134 QVSWQPPPIYHTNGLLQGYKLIF------EPII-----DDIQPSKD---EVESRKTTALTMVLTG 1184

Human   848 -------------------PVEAKP-ECQETETKP-APAEVKTVPNDA 874
                               .|.:|| .|...|..| |||::|.|.:.:
  Fly  1185 LRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPEAPADIKVVSSSS 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	24/119 (20%)
		IG	124..190	CDD:214652	25/142 (18%)
		Ig	211..307	CDD:325142	26/97 (27%)
		Ig	306..438	CDD:325142	29/132 (22%)
		Ig_3	447..519	CDD:316449	22/77 (29%)
		FN3	534..631	CDD:238020	27/107 (25%)
		fn3	639..720	CDD:306538	25/92 (27%)
		Trypan_PARP	<792..>864	CDD:330686	20/93 (22%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	1/1 (100%)
		Ig	247..327	CDD:299845	1/1 (100%)
		I-set	332..418	CDD:254352	24/95 (25%)
		IGc2	344..407	CDD:197706	17/72 (24%)
		IG_like	432..517	CDD:214653	10/84 (12%)
		IGc2	436..507	CDD:197706	10/70 (14%)
		I-set	521..610	CDD:254352	20/91 (22%)
		IGc2	533..597	CDD:197706	16/66 (24%)
		Ig	630..699	CDD:143165	17/68 (25%)
		IG_like	714..802	CDD:214653	28/124 (23%)
		Ig	725..802	CDD:299845	27/113 (24%)
		Ig	823..894	CDD:143165	22/70 (31%)
		FN3	906..1006	CDD:238020	27/105 (26%)
		FN3	1013..1111	CDD:238020	28/108 (26%)
		FN3	1119..1209	CDD:238020	21/131 (16%)
		FN3	1219..1313	CDD:238020	6/14 (43%)
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810