DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM1 and ImpL2

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster

Alignment Length:	304	Identity:	74/304 - (24%)
Similarity:	111/304 - (36%)	Gaps:	97/304 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   267 DDSSQLTIKKVDKNDEAEYICIAE---NKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
            |||:.     ||.:.|||    .|   |:|.|.|   .|| |.|...|.::......:|    :.
  Fly    32 DDSND-----VDNSIEAE----EEKPRNRAFEAD---WLK-FTKTPPTKLQQADGATIE----IV 79

Human   329 CEASGDPIPSITW------RTSTRNISSEEKASWTRPEKQEVHAPWNWQVGRQKGQAGSAGFPGS 387
            ||..|..:|||.|      |:...::.|.:.|.                      :|.||
  Fly    80 CEMMGSQVPSIQWVVGHLPRSELDDLDSNQVAE----------------------EAPSA----- 117

Human   388 HETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD-------SQSMYLEVQYAPKLQ 445
                  .:.|||...:..:..::..||..|.   |.|.||...       |..:..|..| |..|
  Fly   118 ------IVRVRSSHIIDHVLSEARTYTCVGR---TGSKTIYASTVVHPPRSSRLTPEKTY-PGAQ 172

Human   446 GPVAVYTWE------GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKI-----YNTPSASY 499
            .|..:||.:      |:.:.:.|.|.|.|.|.|:|.         |..|.:|     :...:...
  Fly   173 KPRIIYTEKTHLDLMGSNIQLPCRVHARPRAEITWL---------NNENKEIVQGHRHRVLANGD 228

Human   500 LEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ 543
            |.::.....|.|||.|.|.|.:|:::       |||...|.:::
  Fly   229 LLISEIKWEDMGNYKCIARNVVGKDT-------ADTFVYPVLNE 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652
		Ig	211..307	CDD:325142	16/42 (38%)
		Ig	306..438	CDD:325142	27/144 (19%)
		Ig_3	447..519	CDD:316449	21/82 (26%)
		FN3	534..631	CDD:238020	3/10 (30%)
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	19/72 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900