DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM1 and CG13506

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	400	Identity:	78/400 - (19%)
Similarity:	144/400 - (36%)	Gaps:	109/400 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   128 EFREGEDAVIVCDVVS-SLPPTIIWKHKGRDVILKK----DVRFIVLSNNYLQIRGIKKTDEGTY 187
            |.:.|:|.::.||..: .|...::| :|.|.:|...    ..|...:.||.:.:|.:...|...|
  Fly    80 EAKPGDDVILNCDARNFQLSNAVVW-YKNRIIIANGQNPISQRVQCMLNNSILLRNVSPEDSDDY 143

Human   188 RCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK-DG 251
            .||  ||.:                  :.||   :....:|..::::||.....:.:.::.: |.
  Fly   144 YCE--ILPQ------------------RVRQ---HTALRVGARLSILCDDRDITDRSQTFRQGDH 185

Human   252 EQIE-----QEEDDEKYIFSDDSSQ----------LTIKKVDKNDEAEYICIAENKAGE-QDATI 300
            .::|     .:....|:.|:|.:.|          :.:..||:.:..:|.|:|::.:.. ...|:
  Fly   186 HKLECRTYLPDNATIKWSFNDLNGQPSSVDNQNGVIILDNVDEKNAGDYQCLADDGSRHPPHGTV 250

Human   301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQEVH 365
            |:.|...|.::...:....|......|.|.....||....:....:.:...:|.|.    |..||
  Fly   251 HIDVQYSPIVSTHRHNVNTEKGATAELYCNYRAKPIGRSYFIKDGKTLQLSDKYSL----KDSVH 311

Human   366 APWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 430
                                            ..|.| ::|.::.:..:|.|||:|...|.||
  Fly   312 --------------------------------NDHNR-TTLIVREVTDSDLGEYLCQVENAIG-- 341

Human   431 SQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW-----------FRDGQLLPSS 484
            |..:.:.|.|.|:.. .....|.|||:|            |:.|           ..|.||..|.
  Fly   342 SNEVKVHVSYNPETP-QFEDMTVEGNKV------------TLHWLVRSHQLLSEAMLDYQLTGSY 393

Human   485 NYSNIKIYNT 494
            .:|.:::..|
  Fly   394 TWSTVQVLET 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	16/66 (24%)
		Ig	211..307	CDD:325142	19/112 (17%)
		Ig	306..438	CDD:325142	23/131 (18%)
		Ig_3	447..519	CDD:316449	12/58 (21%)
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	16/66 (24%)
		IGc2	83..146	CDD:197706	15/63 (24%)
		IG_like	176..254	CDD:214653	13/77 (17%)
		Ig	176..239	CDD:299845	10/62 (16%)
		I-set	258..349	CDD:254352	23/129 (18%)
		Ig	275..348	CDD:143165	21/111 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900