DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM1 and Dscam1

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	887	Identity:	200/887 - (22%)
Similarity:	340/887 - (38%)	Gaps:	207/887 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    12 FFLGTAVSLQVDIVPSQGEISVGE------SKFFLC----QVAGDAK----------DKDISWFS 56
            |:.||....:..::|| ||:.:.|      .|.:.|    ::.|:.:          .:.:...|
  Fly   183 FYPGTEYDGKYLVLPS-GELHIREVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGSVS 246

Human    57 P------NGEKLT--------------PNQ-----------------QRISVVWND---DSSSTL 81
            |      |.|.:|              |.|                 ::.:||.||   ..|.||
  Fly   247 PQLSGNGNQEHITLTRVPKMGSVTLMCPAQAYPVPFFRWYKFIEGTTRKQAVVLNDRVKQVSGTL 311

Human    82 TIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP 146
            .|.:|.::|:|.|.|||....|.||..|| :.:...|..|..|..|....|..||..|....:..
  Fly   312 IIKDAVVEDSGKYLCVVNNSVGGESVETV-LTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPI 375

Human   147 PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV- 210
            .|:.|         .||.:.|..|...|:|..:||.|:|.|:|    ..|.:....:....:.:
  Fly   376 KTVSW---------MKDGKAIGHSEPVLRIESVKKEDKGMYQC----FVRNDQESAEASAELKLG 427

Human   211 ----PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY-------I 264
                ||.|  ||.....|...|.||.|.|.|.|.|.|.:||..||::|   .::::|       :
  Fly   428 GRFDPPVI--RQAFQEETMEPGPSVFLKCVAGGNPTPEISWELDGKKI---ANNDRYQVGQYVTV 487

Human   265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC 329
            ..|..|.|.|..|..||...|.|||::|.|..:.:..|.|:..|.|..:|.: |:...|.:.:||
  Fly   488 NGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKK-AIVAGETLIVTC 551

Human   330 EASGDPIPSITWRTSTR-------------------NIS-SEEKASWTRPEK-QEVHA------- 366
            ..:|.||.||.|....|                   |:. :.::|::|...| ||.::
  Fly   552 PVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEV 616

Human   367 ---------PWNWQ----VGR--------QKG------------QAGSAGFPGSHETLDGHMVVR 398
                     |:.::    :|.        |||            .||..||......:..:   |
  Fly   617 QVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTN---R 678

Human   399 SHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITC 462
            ...:.|.:::.|......|...|.|||..|..:.|:.|.|...|: :..|......:|:...:.|
  Fly   679 ISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVEC 743

Human   463 EVFAYPSATISWFR-----DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 522
            :...:|...::|.:     .|:........||::    ....|.|....:.:.|.|.|.|:|.||
  Fly   744 KADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRV----EEGTLHVDNIQKTNEGYYLCEAINGIG 804

Human   523 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVP-ILKYKAEWRAVGEE----VWH 582
            ......|::....|  |...:          :.....|..|.| :|:.:|:    ||:    :|:
  Fly   805 SGLSAVIMISVQAP--PEFTE----------KLRNQTARRGEPAVLQCEAK----GEKPIGILWN 853

Human   583 -----------SKWYDAKEASMEGIVTIVGLK-PETTYAVRLAALNGKGLGEISAASEFKTQPVQ 635
                       :::...:|....|:::.:.:| .|.:.:.....:.....|...|:.....|.|.
  Fly   854 MNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVP 918

Human   636 GEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWK--PEIRLPSGSDHVMLK 698
            ..|.|.|:   :.:.|.|::::..:..||.||:..|::.::...:.|.  ..:.:|..:....::
  Fly   919 EMPYALKV---LDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQ 980

Human   699 SLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPAN 738
            .|.....|.:.:||||..|.|:::..|...:|:  |:..|.|
  Fly   981 KLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQN 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	35/154 (23%)
		IG	124..190	CDD:214652	19/65 (29%)
		Ig	211..307	CDD:325142	36/102 (35%)
		Ig	306..438	CDD:325142	40/192 (21%)
		Ig_3	447..519	CDD:316449	14/76 (18%)
		FN3	534..631	CDD:238020	16/113 (14%)
		fn3	639..720	CDD:306538	18/82 (22%)
		Trypan_PARP	<792..>864	CDD:330686
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653	22/76 (29%)
		Ig	269..340	CDD:143165	20/70 (29%)
		IG_like	353..425	CDD:214653	21/84 (25%)
		IGc2	361..413	CDD:197706	18/64 (28%)
		I-set	433..527	CDD:254352	34/98 (35%)
		IGc2	446..517	CDD:197706	27/73 (37%)
		I-set	533..618	CDD:254352	19/85 (22%)
		IGc2	544..607	CDD:197706	15/62 (24%)
		Ig	641..714	CDD:143165	16/75 (21%)
		IGc2	735..804	CDD:197706	14/72 (19%)
		I-set	819..914	CDD:254352	15/108 (14%)
		Ig	833..921	CDD:299845	15/91 (16%)
		FN3	918..1011	CDD:238020	21/95 (22%)
		FN3	1018..1116	CDD:238020	2/5 (40%)
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810