DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM1 and DIP-zeta

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	104/469 - (22%)
Similarity:	185/469 - (39%)	Gaps:	92/469 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI----FQKLMFKNAPTPQEFREGEDAVI 137
            |.:..|:..:|    |:   :|.|...:...:.:|:.:    |.:.: :|...|    .|.:..:
  Fly    80 SGTGSTVVGSN----GV---IVAGGGANVPTSNLNIVVEEPEFTEYI-ENVTVP----AGRNVKL 132

Human   138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN----------------YLQIRGIKKTDEGT 186
            .|.|.:.....:.|.|..:..||  .|...|::.|                ||.|..:.:.|.|.
  Fly   133 GCSVKNLGSYKVAWMHFEQSAIL--TVHNHVITRNPRISVTHDKHDRHRTWYLHINNVHEEDRGR 195

Human   187 YRCE-GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
            |.|: ..:.|:.:..:.::.|..|:..::.:...||...||    ::|.|.|.|.|.|.:.|.:|
  Fly   196 YMCQINTVTAKTQFGYLNVVVPPNIDDSLSSSDVIVREGAN----ISLRCRASGSPRPIIKWKRD 256

Human   251 GEQIEQEEDDEKYIFSD-DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK-PKITYV 313
            ..  .:...::.:|.:: :...|.|.::.:.|...|:|||.|.. ....:..:||... |.:..:
  Fly   257 DN--SRIAINKNHIVNEWEGDTLEITRISRLDMGAYLCIASNGV-PPTVSKRIKVSVDFPPMLLI 318

Human   314 ENQTAMELEE-QVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQEVHAPWNWQVGRQKG 377
            .:|.....|. .||:.|.....| .|:.:              |||.|...:|....::|
  Fly   319 PHQLVGAPEGFNVTIECFTEAHP-TSLNY--------------WTRGEGPIIHDSHKYKV----- 363

Human   378 QAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP 442
             ..:.|.| :::|   ||         .||:.::...|.|.|.|.|.|..|:....:.|.|.|.|
  Fly   364 -EATVGLP-AYKT---HM---------KLTIINVSSGDDGIYKCVAKNPRGETDGIIRLYVSYPP 414

Human   443 KLQGPVAVYT----WEGNQVNITCEVFAY--PSATIS-WFRDGQLLPSSNYSNIKIYNTPSASYL 500
            ..... .:|:    |..|.:|   ..:||  |.:|.| :.:|......||.:.|.:  :...|:|
  Fly   415 TTASS-GIYSTDTHWGENGIN---NNYAYGGPDSTRSIYAQDKNTRYQSNLNEIGL--SEQKSFL 473

Human   501 EVTPDSENDFGNYN 514
            :.|.:.....||.|
  Fly   474 DKTQNPLLANGNAN 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	7/41 (17%)
		IG	124..190	CDD:214652	17/81 (21%)
		Ig	211..307	CDD:325142	23/96 (24%)
		Ig	306..438	CDD:325142	29/133 (22%)
		Ig_3	447..519	CDD:316449	19/75 (25%)
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	20/101 (20%)
		Ig	130..200	CDD:143165	16/71 (23%)
		I-set	226..310	CDD:254352	23/90 (26%)
		IGc2	233..298	CDD:197706	19/70 (27%)
		Ig	313..410	CDD:299845	29/130 (22%)
		IG_like	325..410	CDD:214653	27/118 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910