DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM1 and DIP-theta

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	425	Identity:	95/425 - (22%)
Similarity:	166/425 - (39%)	Gaps:	74/425 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    25 VPSQGE------ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQ-------QRISVVWNDD 76
            :|..||      :.|.......| |..:.:...|:|...:.:.:...|       .|:|:...:.
  Fly   129 LPKFGELLQNVTVPVSREAVLQC-VVDNLQTYKIAWLRVDTQTILTIQNHVITKNHRMSITHAEK 192

Human    77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
            .:..|.|.:....|.|.|.|.:..:........::|.:...::.....|....|||.:..:.|..
  Fly   193 RAWILRIRDVKESDKGWYMCQINTDPMKSQVGYLDVVVPPDILDYPTSTDMVIREGSNVTLKCAA 257

Human   142 VSSLPPTIIWKHKGRDVI-LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG--EINFKD 203
            ..|..|||.|:.:|.::| |......:..:.::|.|..:.:.:.|.|.|   |.:.|  ....|.
  Fly   258 TGSPTPTITWRREGGELIPLPNGAEAVAYNGSFLTIAKVNRLNMGAYLC---IASNGIPPTVSKR 319

Human   204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD------GEQIEQEEDDEK 262
            :.:||:.||.|..:..:|.|.  |.|::||.|.:|.:|:....|.|:      ||:...|..:..
  Fly   320 VMLIVHFPPMIWIQNQLVGAA--LTQNITLECQSEAYPKSINYWMKNDTIIVPGERFVPETFESG 382

Human   263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
            |..   :.:|||.:||..|...|.|:|:|..|:.|..|        |:.::...|.|   ..:..
  Fly   383 YKI---TMRLTIYEVDIQDFGAYRCVAKNSLGDTDGAI--------KLYHIPQTTTM---TTMAP 433

Human   328 TCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQEVHAPWNWQVGR-------QKGQAGSAG-- 383
            |...:..|:..:.:....|..||:...:          .|:|:..|.       |:|::.|.|
  Fly   434 TVSINTVPVVLVKYNKEQRYGSSQNSNT----------NPYNFNPGNSQQNTKLQRGKSNSKGSD 488

Human   384 ---------FPGSHETL----DGHMVVRSHARVSS 405
                     |.|:..:|    |.|....|.:..||
  Fly   489 QSPSGLNNVFVGATSSLWNSQDHHSSSSSSSSASS 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	18/102 (18%)
		IG	124..190	CDD:214652	17/66 (26%)
		Ig	211..307	CDD:325142	31/101 (31%)
		Ig	306..438	CDD:325142	23/122 (19%)
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	15/93 (16%)
		IG_like	137..230	CDD:214653	15/93 (16%)
		IG_like	240..324	CDD:214653	21/86 (24%)
		IGc2	247..310	CDD:197706	17/65 (26%)
		Ig	327..419	CDD:299845	31/104 (30%)
		IG_like	343..420	CDD:214653	26/87 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910