DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NCAM1 and bdl

DIOPT Version :9

Sequence 1:NP_001229536.1 Gene:NCAM1 / 4684 HGNCID:7656 Length:884 Species:Homo sapiens
Sequence 2:NP_608822.1 Gene:bdl / 33635 FlyBaseID:FBgn0028482 Length:719 Species:Drosophila melanogaster


Alignment Length:661 Identity:149/661 - (22%)
Similarity:241/661 - (36%) Gaps:161/661 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   174 LQIRGIKKTDEGTYRCE-------GRILARGEINFKDIQ--VIVNVPPTIQARQNIVNATANLGQ 229
            :.:..|:::|:|.|.|:       ..:...|......:|  .::.:||        ||.|...||
  Fly   110 VNLTAIRESDQGWYHCQVSFPN
RSPSVRNNGTAYHLAVQGGSLIRIPP--------VNQTIREGQ 166

Human   230 SVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG 294
            :....|..:.......||.|||..:::.:|..:..:......|:|.....:|..||.|...|..|
  Fly   167 TAFFHCVMKHPENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDG 231

Human   295 E-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE-ASGDPIPSITWRTSTRNISSEEKASWT 357
            | |.|...|.:..|.|:.|...:..:...:...|.|. .:..|:.::.|                
  Fly   232 ELQTAKAFLNIQYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRW---------------- 280

Human   358 RPEKQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICT 422
              ||..:             ...|...||....::|           ||....:....||.|.||
  Fly   281 --EKDGL-------------LFDSYNVPGVFYKMNG-----------SLFFAKVDENHAGSYTCT 319

Human   423 ASNTIGQDSQSMYLEV-QYAPKLQG--PVAVYTWE-GNQVNITCEVF-----AYPSATISWFR-D 477
            ..|.:|.|..|..:.| ...|.:..  |.|:|..: |....:.||..     ..||  |.|.| |
  Fly   320 PYNDLGTDGPSPVISVIV
LRPPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNNRPS--IIWGRKD 382

Human   478 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF-ILVQADTPSSPSI 541
            ||.||:..:|       .|...|.:|...|.|.|.|.|:|.|.....:.|. ::::...|.:   
  Fly   383 GQPLPADRFS-------LSGGNLTITGLVEGDRGIYECSATNEAATITAEAEL
MIENIAPRA--- 437

Human   542 DQVEPYSSTAQVQFDEPEATGGV--------PILKYKAEWRAVGEEVWHS-KWYDAKEASMEGIV 597
                ||:.||    :..|....:        |.|:|...:|.:....|.: :..|.|  .||  .
  Fly   438 ----PYNLTA----NSTETCITIRWQPGYLRPNLEYTVWYRLMEAPEWRTLRVLDKK--VME--A 490

Human   598 TIVGLKPETTYAVRLAALNGKGLGEIS------------AASEFKTQPVQ---GEPSAPKLEGQM 647
            |:..|:|...|...:.:.:..|.|..|            .|.:|..|.:|   |:.:||  .|.:
  Fly   491 TVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQT
LPSPIRADDFDAQQLQHDLGQVTAP--AGGL 553

Human   648 GEDGNSIKVN-----LIKQD---DGGSPIRHYLVRYRALSSEWK-PEIRL----PSGSDHVMLKS 699
            |...|...::     |:..:   .|...:|.|.||:      || ||..|    .:..::..|:.
  Fly   554 GAPWNLTAISNQQGWLLHWEHPVQGLEGLRLYAVRW------WKEPEHFLIGHAETFDNYYQLRH 612

Human   700 LDWNAEYEVYVVA---ENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLL 761
            |..:..::|.|:|   |.||  |..:|.:.      ..:|:. .....|..|:.||::.::..| 
  Fly   613 LKEDTLFKVQVLAVGTETQQ--SVPSHELL------IDVPSQ-RKVRALIIGSSVGVIFLLCAL- 667

Human   762 LVVVDITCYFL 772
                   |.||
  Fly   668 -------CAFL 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NCAM1NP_001229536.1 Ig1_NCAM-1 20..115 CDD:143273
IG 124..190 CDD:214652 4/15 (27%)
Ig 211..307 CDD:325142 26/96 (27%)
Ig 306..438 CDD:325142 24/132 (18%)
Ig_3 447..519 CDD:316449 26/78 (33%)
FN3 534..631 CDD:238020 24/117 (21%)
fn3 639..720 CDD:306538 24/96 (25%)
Trypan_PARP <792..>864 CDD:330686
bdlNP_608822.1 IG_like 42..128 CDD:214653 5/17 (29%)
Ig 43..131 CDD:299845 5/20 (25%)
I-set 153..242 CDD:254352 26/96 (27%)
Ig 157..242 CDD:299845 25/92 (27%)
Ig_2 252..337 CDD:290606 22/126 (17%)
IG_like 260..327 CDD:214653 19/108 (18%)
I-set 341..428 CDD:254352 28/95 (29%)
IGc2 356..419 CDD:197706 24/71 (34%)
FN3 435..524 CDD:238020 22/103 (21%)
FN3 554..636 CDD:238020 22/89 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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