DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM1 and CG33543

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	103/457 - (22%)
Similarity:	173/457 - (37%)	Gaps:	58/457 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    18 VSLQVDIVPSQGEIS--VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST 80
            :|||    ||...|:  |.||....||..  .||.|..|..|.|:.....:.|:.:.........
  Fly    48 LSLQ----PSTPSITHFVNESFIIFCQTV--QKDIDTKWRDPRGQTRENTKGRVHIEKKTTGLLA 106

Human    81 LTIYNANIDDAGIYKCVVTG-EDGSESEATVNVK----------IFQKLMFKNAPTPQEFREGED 134
            |...:..::|.|.:.|.|.| .:|:.:   |||:          :.||:.|......|..|||.|
  Fly   107 LVFEHIALEDRGNWTCEVNGNRNGNRN---VNVEREFLASFELLVNQKISFGKTEQVQSVREGRD 168

Human   135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
            |::.|.|.....|.:.|.:.|..:......:...|||. |.||.:.:.|.|.|.|....:.....
  Fly   169 AMVNCFVEGMPAPEVSWLYNGEYINTVNSTKHNRLSNG-LYIRNVSQADAGEYTCRAMRITPTFS 232

Human   200 NFKDIQVIVNV--PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
            :...|.:::.:  .|.....:.:....|.:|.:|.|.|||.|.|.|:.:|..:.:.|  ...:.:
  Fly   233 DSDQITILLRIQHKPHWFFNETLPVQYAYVGGAVNLSCDAMGEPPPSFTWLHNNKGI--VGFNHR 295

Human   263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
            ...:|..:.|.::..:.:...:|.|...|..|..:..|.|:...||.     .....:|::..|
  Fly   296 IFVADYGATLQLQMKNASQFGDYKCKVANPLGMLERVIKLRPGPKPL-----GPRRFQLKKLYT- 354

Human   328 TCEASGDPIPSITWRTSTRNISSEEKASWTR----PEKQEVHAPWNWQVGRQKGQAGSAGFPGSH 388
                :|..:...|.|.|  |:|.|.:....|    .:.:...:..||...:|:    ...|.|..
  Fly   355 ----NGFELDIQTPRMS--NVSDEMQIYGYRVAYMSDTEFKFSAGNWSYAKQR----DFSFHGGK 409

Human   389 ETLDGHMVVRSH--ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVY 451
            ..:..|:...:.  .|.:|..|..:......:...||:..    |.|.:|...|     |.:...
  Fly   410 HFIIPHLETNTTYLMRAASRNLAGLSDWSPVKVFTTAAGC----SWSPWLYPSY-----GLILAL 465

Human   452 TW 453
            .|
  Fly   466 IW 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	27/107 (25%)
		IG	124..190	CDD:214652	20/65 (31%)
		Ig	211..307	CDD:325142	21/95 (22%)
		Ig	306..438	CDD:325142	26/137 (19%)
		Ig_3	447..519	CDD:316449	1/7 (14%)
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	19/59 (32%)
		IG_like	256..336	CDD:214653	19/81 (23%)
		IGc2	263..327	CDD:197706	16/65 (25%)
		FN3	341..445	CDD:238020	20/119 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I11036
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910