DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM1 and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	344	Identity:	82/344 - (23%)
Similarity:	142/344 - (41%)	Gaps:	54/344 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    11 LFFLGTAVSLQVD-------------IVPSQG-EISVGESKFFLC--------QVAGDAKD--KD 51
            |..||..:.|.|.             ::|.:. .|:.|....|.|        :|:||...  ..
  Fly    75 LLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAK 139

Human    52 ISWFSPNG-------EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEAT 109
            ::|...:.       |.:..|..|:||..||.::.||.|....::|||.|.|.|..:......||
  Fly   140 VAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQTAT 204

Human   110 VNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK-GRDVILK----KDVRFIVL 169
            :.|.|...::.:.........||..|.:||.......|.|.|:.: ||::|.:    :..:...:
  Fly   205 LEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQKTKAQSV 269

Human   170 SNNYLQIRGIKKTDEGTYRCEGRILARG--EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVT 232
            ....|.:..|.:::.|.|.|   |.:.|  ....|.:::.|:..|.:|....:|.|.  :...||
  Fly   270 EGEMLTLSKITRSEMGAYMC---IASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAP--VLTDVT 329

Human   233 LVCDAEGFPEPTMSWTKD-GEQIEQEEDDEKYIFSDDSSQ-------LTIKKVDKNDEAEYICIA 289
            |:|:.|..|:....|.:: ||.|..   .::|..::..:.       |.||::..:|...|.||:
  Fly   330 LICNVEASPKAINYWQRENGEMIIA---GDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCIS 391

Human   290 ENKAGEQDATIHLKVFAKP 308
            :|..|:.:.||.|....:|
  Fly   392 KNSIGDTEGTIRLYEMERP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	30/125 (24%)
		IG	124..190	CDD:214652	15/70 (21%)
		Ig	211..307	CDD:325142	27/103 (26%)
		Ig	306..438	CDD:325142	1/3 (33%)
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	28/110 (25%)
		ig	102..195	CDD:278476	25/92 (27%)
		IG_like	219..307	CDD:214653	19/90 (21%)
		Ig	221..307	CDD:299845	19/88 (22%)
		Ig	311..404	CDD:299845	26/97 (27%)
		IG_like	327..405	CDD:214653	22/80 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910