DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM1 and dpr18

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	277	Identity:	61/277 - (22%)
Similarity:	101/277 - (36%)	Gaps:	99/277 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    41 CQVAGDAKDKDISWFSPNGEKLT---------PNQQRISVVWNDDSSSTLTIYNANIDDAGIYKC 96
            |:| |..|||.:.|.....||::         ....||.|.:...::..|.|.....:|||:|.|
  Fly   246 CRV-GMLKDKTVMWVRRTAEKVSLLTVGNVTYSGDPRIRVKFQYPNNWRLLINPTQTEDAGVYMC 309

Human    97 VVT----------------------------GEDGSESEATVNVK------IFQK---LMFKNAP 124
            .|:                            |:...:|.:||:::      .|||   .:.|:..
  Fly   310 QVSTHPPRVFTTNLTVLEPPLRIIDEHERDVGDRYYKSGSTVDLQCQISRSFFQKERQTILKSTD 374

Human   125 TPQEFREGEDAV--IVCDVVSSLPPTII-----WKHK--GRDVILKKDVRFIV----------LS 170
            :      ..|||  ::.:..|.|  .:|     .:||  |:| :.|...:||.          ::
  Fly   375 S------ANDAVQKLINETTSEL--NLIGNVNQTQHKFSGQD-LEKYFTKFITWAKDEEPLQGMT 430

Human   171 NNYLQIRGI-----------KKTDEGTYRCE-GRILARGEINFKDIQVIV-NVPPTIQARQNIVN 222
            |..|.:..:           |.:|.|.|.|. ||:..    ....:||:. .:|..:|  .||.:
  Fly   431 NRRLSVSDVWLTSRISIGDAKLSDSGNYSCSLGRLFT----VIVQVQVLTGELPAAVQ--HNIGS 489

Human   223 AT-----ANLGQSVTLV 234
            .|     |.||..:.|:
  Fly   490 RTEIYSLAMLGHLLVLI 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	24/116 (21%)
		IG	124..190	CDD:214652	19/95 (20%)
		Ig	211..307	CDD:325142	9/29 (31%)
		Ig	306..438	CDD:325142
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	20/79 (25%)
		Ig	<258..326	CDD:299845	14/67 (21%)
		IGc2	<417..461	CDD:197706	7/43 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810