DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCAM1 and rst

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	798	Identity:	157/798 - (19%)
Similarity:	268/798 - (33%)	Gaps:	214/798 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    14 LGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS 78
            :|..|:|...::..||.:...:..|      |....:|:|.|           :|.::|.:|:..
  Fly    41 VGARVTLPCRVINKQGTLQWTKDDF------GLGTSRDLSGF-----------ERYAMVGSDEEG 88

Human    79 S-TLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREG------ED-- 134
            . :|.||...:||...|:|.|:  .|.|.:..:. ..|..|.....|...:..:|      ||
  Fly    89 DYSLDIYPVMLDDDARYQCQVS--PGPEGQPAIR-STFAGLTVLVPPEAPKITQGDVIYATEDRK 150

Human   135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL---------SNNYLQIRGIKKTDEGTYRCE 190
            ..|.|..|...|...|....|...:|..::.:.|:         :.:.|::...|:.....:.|:
  Fly   151 VEIECVSVGGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQ 215

Human   191 GRILARGEINFKDIQVIVNVPPTIQARQNIV-----NATANLG------------------QSVT 232
            .:..|........|:|.|...|.::.  |::     .|..::|                  ..|.
  Fly   216 AQNTADRTYRSAKIRVEVKYAPKVKV--NVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVR 278

Human   233 LVCDAEGFP-EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD-KNDEAEYICIAENKAGE 295
            |.|.|:..| :....|..:.|.          |.....:::.|:.|. |..:|...|..:|..|:
  Fly   279 LECRADANPSDVRYRWFINDEP----------IIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGK 333

Human   296 QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE 360
            .:.:..|.:...|...........::...|:||||...:|.|.|.|
  Fly   334 SEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVW------------------- 379

Human   361 KQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASN 425
               :..|.:    |..|.:.:..|..|:||                         ||.|.|.| |
  Fly   380 ---IQHPSD----RVVGTSTNLTFSVSNET-------------------------AGRYYCKA-N 411

Human   426 TIG--QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT-ISWFRDGQLLPSS--- 484
            ..|  :.|...|:.::.:|.:......|...|:...|.|...:.|.|. :||..:||.:.|.
  Fly   412 VPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRARHVSWTFNGQEISSESGH 476

Human   485 NYSNIKIYNTPSA--SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 547
            :|| |.:...|..  |.|.:.......:|.||||.||..|.:..|   :|.....|.|:...
  Fly   477 DYS-ILVDAVPGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAE---IQLQAKKSVSLLMT--- 534

Human   548 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRL 612
                        ..||:.::.:..                        ::||:       ..|.:
  Fly   535 ------------IVGGISVVAFLL------------------------VLTIL-------VVVYI 556

Human   613 AALNGKGLGEISAASEFKTQPVQGEPSAPKLE-GQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYR 676
            .......|......||.  |..:....:.||| |....:.:.:||::    .||      .|.|.
  Fly   557 KCKKRTKLPPADVISEH--QITKNGGVSCKLEPGDRTSNYSDLKVDI----SGG------YVPYG 609

Human   677 ALSSEWKPEIRL-------PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTA 734
            ..|:.:.|..:.       .:||..:|..:      ::..:..:.||.:|...|.. :|:..|..
  Fly   610 DYSTHYSPPPQYLTTCSTKSNGSSTIMQNN------HQNQLQLQQQQQQSHHQHHT-QTTTLPMT 667

Human   735 IPANGSPTSGLSTGAIVG 752
            ...|.|  .|..||:|:|
  Fly   668 FLTNSS--GGSLTGSIIG 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	21/95 (22%)
		IG	124..190	CDD:214652	14/82 (17%)
		Ig	211..307	CDD:325142	20/120 (17%)
		Ig	306..438	CDD:325142	26/133 (20%)
		Ig_3	447..519	CDD:316449	22/77 (29%)
		FN3	534..631	CDD:238020	10/96 (10%)
		fn3	639..720	CDD:306538	17/88 (19%)
		Trypan_PARP	<792..>864	CDD:330686
rst	NP_001284835.1	IG_like	34..130	CDD:214653	25/108 (23%)
		Ig	42..114	CDD:299845	22/90 (24%)
		C2-set_2	135..225	CDD:285423	15/89 (17%)
		Ig_3	265..329	CDD:290638	13/73 (18%)
		I-set	346..420	CDD:254352	24/125 (19%)
		Ig	360..425	CDD:299845	25/116 (22%)
		Ig5_KIRREL3-like	428..524	CDD:143235	28/99 (28%)
		IG_like	435..524	CDD:214653	27/92 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810