DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM1 and dpr7

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001096850.2	Gene:	dpr7 / 2768865	FlyBaseID:	FBgn0053481	Length:	312	Species:	Drosophila melanogaster

Alignment Length:	225	Identity:	52/225 - (23%)
Similarity:	83/225 - (36%)	Gaps:	67/225 - (29%)

- Green bases have known domain annotations that are detailed below.

Human     8 IWTLFFLGTA-VSLQ----------VDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNG-E 60
            ||..:...|: :||.          .||.|......|.|.....|:|.... ::.:||..... .
  Fly    29 IWCQYISATSYLSLNDLTNLERPFFDDISPRNVSAVVDEIAILRCRVKNKG-NRTVSWMRKRDLH 92

Human    61 KLTPN------QQRISVVWNDDSSS-TLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKL 118
            .||.|      .||.||:....|.. .|.|..|...|:|:|:|.|      .:|..:|:.|..::
  Fly    93 ILTTNIYTYTGDQRFSVIHPPGSEDWDLKIDYAQPRDSGVYECQV------NTEPKINLAICLQV 151

Human   119 M----FKNAPTPQEFREGEDA------------------VIVCDVVSSLPPTIIWKHKGRDVILK 161
            :    |::..|.:.|.:.:.|                  .:.|. |:...|::||.| |..|:
  Fly   152 IADNDFQDLKTKKRFYDTKSARAKILGSTEIHVKRDSTIALACS-VNIHAPSVIWYH-GSSVV-- 212

Human   162 KDVRFIVLSNNYLQIRG-----IKKTDEGT 186
                      ::..:||     .:|||.||
  Fly   213 ----------DFDSLRGGISLETEKTDVGT 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	28/112 (25%)
		IG	124..190	CDD:214652	18/86 (21%)
		Ig	211..307	CDD:325142
		Ig	306..438	CDD:325142
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
dpr7	NP_001096850.2	V-set	56..145	CDD:284989	25/95 (26%)
		IG_like	58..140	CDD:214653	23/88 (26%)
		IG_like	179..265	CDD:214653	15/68 (22%)
		Ig	187..257	CDD:299845	15/60 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910