DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCAM1 and dpr1

DIOPT Version :9

Sequence 1:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens
Sequence 2:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster

Alignment Length:	238	Identity:	57/238 - (23%)
Similarity:	95/238 - (39%)	Gaps:	41/238 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    25 VPSQGEISVGESKFFLCQVAGDAKDKDISW--------FSPNGEKLTPNQQRISVVWNDDSSS-T 80
            ||....::||::.|..|:|. ...|||:||        .:..|...| :.||..|:..|.|:: |
  Fly    59 VPRNLTVTVGQTGFLHCRVE-RLGDKDVSWIRKRDLHILTAGGTTYT-SDQRFQVLRPDGSANWT 121

Human    81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSL 145
            |.|......|:|:|:|.:..|.......|.||...:..:|  .|:....:.|.|..:.|.::..
  Fly   122 LQIKYPQPRDSGVYECQINTEPKMSLSYTFNVVELKAEIF--GPSDLMVKTGSDINLTCKIMQG- 183

Human   146 PP----TIIWKHKGRDVILKKDVRFIVLS--------------NNYLQIRGIKKTDEGTYRCEGR 192
             |    .|.| :||.:::..|....|..|              .:.|:|:.....|.|.|.|...
  Fly   184 -PHELGNIFW-YKGSEMLDGKGENEIDSSMARIRVEDDWTDGLTSRLKIKRAMPGDTGNYTCVPT 246

Human   193 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVC 235
            :.....:.   :.||:...|.  |.|:  |:::|.......:|
  Fly   247 VAKTSSVY---VHVIIGEHPA--AMQH--NSSSNSNSFYCGIC 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	30/98 (31%)
		IG	124..190	CDD:214652	17/83 (20%)
		Ig	211..307	CDD:325142	6/25 (24%)
		Ig	306..438	CDD:325142
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	29/96 (30%)
		IG_like	60..150	CDD:214653	26/91 (29%)
		IG_like	163..257	CDD:214653	18/99 (18%)
		Ig	174..244	CDD:143165	14/72 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810